肺气肿动物模型研究进展

doi:10.19983/j.issn.2096-8493.20210157

摘要/Abstract

摘要：

慢性阻塞性肺疾病(COPD)是一种常见的慢性呼吸系统疾病,患病率与病亡率均较高。肺气肿是COPD主要的病理表现之一,其发生发展与蛋白酶-抗蛋白酶失衡、氧化应激、细胞炎症、细胞凋亡等有关。但是,目前关于肺气肿的发病机制及病程进展的原因尚未完全阐明,建立疾病动物模型为进一步了解其生理病理机制提供了有效且有实践意义的实验平台。本研究对既往已建立的肺气肿动物模型方法及相关进展进行综述。

关键词: 肺疾病,慢性阻塞性, 疾病模型,动物, 综述文献(主题)

Abstract:

Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease with high morbidity and mortality. Emphysema is one of the main pathological manifestations of COPD whose development was related to protease-antiprotease imbalance, oxidative stress, cell inflammation, cell apoptosis and so on. However, the pathogenesis and mechanism of progression of emphysema have not been fully clarified. The establishment of disease animal model provides an effective and practical experimental platform for further understanding its physiological and pathological mechanism. This article reviews the established animal models of emphysema, methods and related progresses based on previous researches.

Key words: Pulmonary disease,chronic obstructive, Disease models,animal, Review literature as topic

中图分类号:

罗丽娟, 陈燕. 肺气肿动物模型研究进展[J]. 结核与肺部疾病杂志, 2022, 3(1): 60-64. doi: 10.19983/j.issn.2096-8493.20210157

LUO Li-juan, CHEN Yan. Research progress of animal models of emphysema[J]. Journal of Tuberculosis and Lung Disease, 2022, 3(1): 60-64. doi: 10.19983/j.issn.2096-8493.20210157

图/表 1

参考文献 51

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建模方法	优点	缺点
香烟烟雾暴露诱发的肺气肿模型	与人类吸烟诱导的发病过程相似,产生类似于人类的生理变化,包括肺气肿、气流阻塞和肺动态顺应性降低等;低成本	建模周期相对较长
香烟烟雾提取物腹腔注射诱导的肺气肿模型	操作简单,建模周期短,低成本	与人类肺气肿的发展过程不完全一致
弹性蛋白酶诱导的肺气肿模型	操作简单,建模周期短,快速起病,低成本	弹性蛋白诱导的急性起病与人类肺气肿慢性进展不完全一致
化学物质刺激诱导的肺气肿模型	操作简单,建模周期短,低成本	与人类肺气肿的发展过程不完全一致
与基因相关诱导的肺气肿模型	阐明各种不同的基因在肺气肿发病机制中的作用	技术要求及成本较高