结核分枝杆菌Mce4蛋白家族研究进展

doi:10.19983/j.issn.2096-8493.20220089

结核与肺部疾病杂志 ›› 2022, Vol. 3 ›› Issue (5): 415-419.doi: 10.19983/j.issn.2096-8493.20220089

结核分枝杆菌Mce4蛋白家族研究进展

刘原园¹, 李璐², 吴托雅³, 鲁洁¹()

1.国家儿童医学中心/首都医科大学附属北京儿童医院/北京市儿科研究所耳鼻喉研究室,北京 100045
2.首都医科大学附属北京胸科医院细菌免疫室,北京 101149
3.内蒙古自治区通辽市传染病医院结核病科,通辽 028000

收稿日期:2022-05-13 出版日期:2022-10-20 发布日期:2022-10-14
通信作者: 鲁洁 E-mail:lujiebch@163.com
基金资助:
国家自然科学基金(81401739);北京市优秀人才(2018000021469G277);北京市医院管理中心儿科学科协同发展中心专项经费(XTCX201806)

Research progress on the Mce4 protein family of Mycobacterium tuberculosis

Liu Yuanyuan¹, Li Lu², Wu Tuoya³, Lu Jie¹()

1. Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China
2. Department of Bacteriology and Immunology, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China
3. Department of Tuberculosis Diseases, Tongliao Infectious Disease Hospital, Inner Mongolia, Tongliao 028000, China

Received:2022-05-13 Online:2022-10-20 Published:2022-10-14
Contact: Lu Jie E-mail:lujiebch@163.com
Supported by:
National Natural Science Foundation of China(81401739);Beijing Talent Training Funded Project(2018000021469G277);With The Special Fund of The Pediatric Medical Coordinated Development Center of Beijing Municipal Administration of Hospitals(XTCX201806)

摘要/Abstract

摘要：

由结核分枝杆菌引起的结核病自2007年以来一直位居单一传染性疾病死因之首。结核病流行的主要原因是由于结核分枝杆菌能在宿主细胞内长期休眠,对宿主防御和药物治疗具有很强的抵抗力。结核分枝杆菌的哺乳动物细胞入侵(mammalian cell entry,Mce)蛋白家族在其侵袭和细胞内存活中起着重要作用,Mce蛋白家族有4个mce操纵子(mce1-4)编码。其中,mce4操纵子及其编码的Mce4蛋白家族在诱导病原菌入侵、调控宿主免疫、摄取利用胆固醇的过程中至关重要。笔者综述了mce4操纵子及Mce4蛋白家族的研究进展,以便对Mce4蛋白在结核分枝杆菌发病机制中的作用有更深入的认识。同时,也能为结核病的治疗提供潜在的新靶点。

关键词: 分枝杆菌,结核, 免疫蛋白质类, 操纵子, 综述文献(主题)

Abstract:

Tuberculosis (TB) caused by Mycobacterium tuberculosis has been the first cause of death for single infectious diseases since 2007. An indispensable cause of TB epidemic is that M.tuberculosis can dormant in host cells for a long time, and it has strong resistance to host defense and drug treatment. Mammalian cell entry (Mce) protein family plays a major role in M.tuberculosis invasion and intracellular survival.Among them, the mce operons (mce1-4) and the encoded Mce4 protein family are essential in the process of inducing pathogenic bacteria invasion, regulating host immunity, and ingesting and utilizing cholesterol. The authors reviews the research progress of mce4 operon and Mce4 protein family, to further comprehend the role of Mce4 proteins in the pathogenesis of M.tuberculosis and provide potential new targets for the treatment of tuberculosis.

Key words: Mycobacterium tuberculosis, Immunoproteins, Operon, Review literature as topic

中图分类号:

刘原园, 李璐, 吴托雅, 鲁洁. 结核分枝杆菌Mce4蛋白家族研究进展[J]. 结核与肺部疾病杂志, 2022, 3(5): 415-419. doi: 10.19983/j.issn.2096-8493.20220089

Liu Yuanyuan, Li Lu, Wu Tuoya, Lu Jie. Research progress on the Mce4 protein family of Mycobacterium tuberculosis[J]. Journal of Tuberculosis and Lung Disease, 2022, 3(5): 415-419. doi: 10.19983/j.issn.2096-8493.20220089

图/表 1

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结核分枝杆菌Mce4蛋白家族研究进展

Research progress on the Mce4 protein family of Mycobacterium tuberculosis

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