结核与肺部疾病杂志 ›› 2022, Vol. 3 ›› Issue (4): 309-314.doi: 10.19983/j.issn.2096-8493.20220011
收稿日期:
2022-01-28
出版日期:
2022-08-20
发布日期:
2022-08-16
通信作者:
吕良敬
E-mail:lu_liangjing@163.com
基金资助:
Li Yuan, Guo Ruru, Lyu Liangjing()
Received:
2022-01-28
Online:
2022-08-20
Published:
2022-08-16
Contact:
Lyu Liangjing
E-mail:lu_liangjing@163.com
Supported by:
摘要:
结缔组织病是引起多系统功能障碍的自身免疫病,结核病是危害人民生命健康的重要传染病。结缔组织病患者患结核病风险较一般人群高,其临床表现不典型,诊疗难度大,且预后差。作者针对结缔组织病合并结核病的流行状况、危险因素、临床特点、筛查与治疗策略进行综述,为结缔组织病合并结核病的筛查、预防和控制提供最新的研究进展。
中图分类号:
郦源, 郭茹茹, 吕良敬. 结缔组织病合并结核病的研究进展[J]. 结核与肺部疾病杂志, 2022, 3(4): 309-314. doi: 10.19983/j.issn.2096-8493.20220011
Li Yuan, Guo Ruru, Lyu Liangjing. Research progress of connective tissue disease and tuberculosis comorbidity[J]. Journal of Tuberculosis and Lung Disease, 2022, 3(4): 309-314. doi: 10.19983/j.issn.2096-8493.20220011
图1
CTD患者结核病筛查流程 注 TST:结核菌素皮肤试验; IGRA:γ-干扰素释放试验; LTBI:结核分枝杆菌潜伏感染; ATB:活动性结核病; a:满足以下任一条件的CTD患者必须采用IGRA检测:(1)有卡介苗接种史;(2)来自非结核分枝杆菌病高流行地区;(3)长期使用GC或ISA; b:灰色区域指TST在5~10mm或QFT的IFN-γ 在0.045~0.35IU/ml; c:对于TST或IGRA筛查阴性,但有结核临床指征患者,也可考虑胸部X线检查; d:获取呼吸道(例如,痰液、支气管肺泡灌洗液)或其他临床上适合于抗酸杆菌涂片和分枝杆菌培养的样本,必要时可采用Xpert等分子诊断技术; e:在结核低风险地区,出现新的结核病暴露时重新筛查LTBI,结核中高风险地区,每年筛查1次
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