关键词: 结核, 肺, 尘肺, 治疗结果, 因素分析, 统计学

Abstract: Objective: To analyze the treatment outcomes and influencing factors of patients with coal worker’s pneumoconiosis complicated with pulmonary tuberculosis, and to provide scientific basis for effective prevention and control of this complication disease.Methods: A total of 122 patients, all male, who were diagnosed and registered as pneumoconiosis complicated with tuberculosis in the Department of Pneumoconiosis and Tuberculosis of Beijing Jingmei Group General Hospital from 2016 to 2021 and completed the prescribed course of anti-tuberculosis treatment were included, excluding the cases of treatment suspension, diagnosis change, or drug resistance. Patients’ demographic characteristics (age, education, drinking history, place of residence, BMI), sources of patients, and disease characteristics (results of etiological examination, stage of pneumoconiosis, working years with dust exposure, lesion location of pulmonary tuberculosis, whether being severe cases, primary or retreatment cases, whether with diabetes mellitus or pulmonary cavity), etc. were collected, then treatment outcome and influencing factors were analyzed.Results: Among the 122 patients, 30 cases were cured and 73 cases completed the course of treatment. The treatment success rate was 84.43% (103/122), and the rate of adverse outcomes was 15.57% (19/122). Three cases (2.46%) died of non-tuberculosis, seven (5.74%) died of tuberculosis, one (0.82%) refused treatment, and eight other cases (6.56%). Multivariate logistic regression analysis showed that patients with stage Ⅰ pneumoconiosis (OR=0.085, 95%CI: 0.013-0.550) and stage Ⅱ pneumoconiosis (OR=0.156, 95%CI: 0.033-0.746) complicated with pulmonary tuberculosis were more likely to gain treatment success. Patients aged 51-65 years old (OR=33.311, 95%CI: 2.184-507.947), patients being referred with symptoms or having sought care with symptoms (OR=14.641, 95%CI: 3.632-59.026), patients with disease condition deemed as severe (OR=164.962, 95%CI: 25.418-1070.603)were more likely to fail in treatment.Conclusion: The poor treatment outcomes of patients with coal worker’s pneumoconiosis complicated with pulmonary tuberculosis was related to referral or seeking care with symptoms, aged 51-65 years old and being severe cases. We should strengthen the active detection of patients and pay attention to 51-65 years old patients and severe cases, to improve the treatment success rate and prognosis.

Key words: Tuberculosis, pulmonary, Pneumoconiosis, Treatment results, Factor analysis, statistical