肿瘤消融术在肺癌中的研究进展

doi:10.3969/j.issn.2096-8493.20210050

摘要/Abstract

摘要：

早期肺癌行根治性手术切除为首选治疗,然而大部分患者确诊时已失去手术时机。他们需寻求化疗、放疗、靶向治疗、免疫治疗、影像引导下消融治疗等非手术治疗方式。肿瘤消融术作为一种微创技术,为不能外科手术治疗的肺癌和肺转移瘤的患者提供一种治疗选择,也被证明是一种安全和有效的治疗方法。肿瘤消融术包括射频消融、微波消融、冷冻消融、激光消融、高强度聚焦超声、不可逆电穿孔术。肿瘤消融治疗的生理学基础是细胞在温度达到60℃以上时发生凝固性坏死和细胞死亡。肿瘤消融治疗可以使患者获得相对较长的生存时间和较好的生活质量,且肿瘤消融治疗具有可重复性,尚未发现有肺功能减退。

关键词: 肺肿瘤, 消融技术, 外科手术, 微创性

Abstract:

Radical resection is the first choice for early lung cancer. However, most patents have lost the chance of operation when they were diagnosed. They have to seek non-surgical treatments, including chemotherapy, radiotherapy, targeted drug therapy, immunotherapy, image guided thermal ablation, etc. Tumor ablation is an important treatment option for nonsurgical lung cancer and pulmonary metastatic patients. It is a minimally invasive alternative to surgical resection, and has been proved to be a safe and effective treatment. The methods of tumor ablation include: radiofrequency ablation, microwave ablation, cryoablation, laser ablation, high-intensity focused ultrasound, and irreversible electroporation. The physiologic basis of thermal ablation is that coagulative necrosis and cell death occur at temperatures above 60℃. Tumor ablation therapy can make patients obtain relatively long survival time and better life quality, as lung ablation provides repeatability and respiratory function worsening has not been observed.

Key words: Lung neoplasms, Ablation techniques, Surgical procedures, minimally invasive

李向南, 张晓菊. 肿瘤消融术在肺癌中的研究进展[J]. 结核与肺部疾病杂志, 2021, 2(3): 256-261. doi: 10.3969/j.issn.2096-8493.20210050

LI Xiang-nan, ZHANG Xiao-ju. Research progress of tumor ablation in lung cancer[J]. Journal of Tuberculosis and Lung Disease, 2021, 2(3): 256-261. doi: 10.3969/j.issn.2096-8493.20210050

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