结核与肺部疾病杂志 ›› 2020, Vol. 1 ›› Issue (3): 276-280.doi: 10.3969/j.issn.2096-8493.2020.03.014
收稿日期:
2020-11-19
出版日期:
2020-12-30
发布日期:
2021-01-05
通信作者:
刘晓清
E-mail:liuxq@pumch.cn
MA Hui-min, ZHANG Li-fan, LIU Xiao-qing()
Received:
2020-11-19
Online:
2020-12-30
Published:
2021-01-05
Contact:
LIU Xiao-qing
E-mail:liuxq@pumch.cn
摘要:
世界卫生组织将潜伏性结核感染(latent tuberculosis infection,LTBI)定义为人体受到结核分枝杆菌抗原刺激后出现持续免疫反应,而没有表现出活动性结核病临床证据的一种状态。全球约1/4的人感染了结核分枝杆菌,其中约5%~10%的感染者最终会进展为活动性结核病。因此,研究LTBI进展为活动性结核病的机制对结核病防控意义重大。作者从结核分枝杆菌感染进程、LTBI进展为活动性结核病的免疫学改变,以及诱发LTBI再活动的危险因素等方面对这一热点问题进行综述。
马慧敏, 张丽帆, 刘晓清. 潜伏性结核感染进展为活动性结核病的机制研究[J]. 结核与肺部疾病杂志, 2020, 1(3): 276-280. doi: 10.3969/j.issn.2096-8493.2020.03.014
MA Hui-min, ZHANG Li-fan, LIU Xiao-qing. Research progress on the mechanism of latent tuberculosis infection progressing to active tuberculosis[J]. Journal of Tuberculosis and Lung Disease, 2020, 1(3): 276-280. doi: 10.3969/j.issn.2096-8493.2020.03.014
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