关键词: 结核, 肺, 糖尿病, 共病现象, 发病率, 治疗结果

Abstract:

Objective To analyze the registration and outcome of diabetes mellitus complicated with pulmonary tuberculosis patients in Xuhui District of Shanghai from 2013 to 2017.Methods The data from the Xuhui District Tuberculosis Management Information System, Disease Control Information Management Platform and electronic medical records of tuberculosis designated hospitals from 2013 to 2017 were collected. The data of diabetes management population were collected from the diabetes subsystem of Disease Control Information Management Platform. From 2013 to 2017, 1383 active tuberculosis patients were registered in Xuhui District of Shanghai, including 903 males and 480 females. Among them, there were 147 cases of diabetes complicated with pulmonary tuberculosis and 1236 cases of pulmonary tuberculosis only. The demographic data was derived from the statistical yearbook of Xuhui District. The clinical data of the two groups were compared and analyzed.Results From 2013 to 2017, 147 cases of diabetes mellitus complicated with pulmonary tuberculosis were registered in Xuhui District of Shanghai, accounting for 10.63% (147/1383) of all registered pulmonary tuberculosis cases. The registered incidence of pulmonary tuberculosis in diabetic patients (54.20/100000-117.18/100000) was about 2.18-4.72 times that of the general population (22.86/100000-28.62/100000). In the group of diabetes mellitus complicated with pulmonary tuberculosis patients, the average age was 64.26±1.06 years, the proportion of male patients was 81.0% (119/147), the proportion of smear positive patients was 57.1% (84/147), the median patient delay time (quartile) (M(Q₁,Q₃)) was 14.0 (5.0,32.0)days, and the average treatment course was 10.90±2.68 months. In the group of pulmonary tuberculosis only patients, the average age was 43.75±0.59 years, the proportion of male patients was 63.4% (784/1236), the proportion of smear positive patients was 37.1% (458/1236), the median patient delay time (quartile) (M(Q₁,Q₃)) was 11.5 (2.0,27.0)days, and the average treatment course was 10.09±3.14 months. There were significant differences in these indicators (t=11.73, χ ²=17.80, χ ²=22.25, Z=-2.22, t=3.16, all Ps<0.05). Conclusion The registration incidence rate of pulmonary tuberculosis in diabetes mellitus patients is higher than that in the general population. The average age, male ratio, smear positive ratio, patient delay time and treatment course of diabetes mellitus complicated with pulmonary tuberculosis patients are higher than those of pulmonary tuberculosis only patients.

Key words: Tuberculosis, pulmonary, Diabetes mellitus, Comorbidity, Incidence, Treatment outcome