儿童哮喘与百日咳关系机制的研究进展

doi:10.19983/j.issn.2096-8493.20220136

结核与肺部疾病杂志 ›› 2023, Vol. 4 ›› Issue (1): 78-84.doi: 10.19983/j.issn.2096-8493.20220136

儿童哮喘与百日咳关系机制的研究进展

闫金燕¹, 李小敏², 马香³()

¹山东大学附属儿童医院感染性疾病科,济南 250022
²山东省聊城市东昌府区妇幼保健院儿科,聊城 252000
³山东大学附属儿童医院呼吸科/济南市儿童呼吸病重点实验室,济南 250022

收稿日期:2022-08-23 出版日期:2023-02-20 发布日期:2023-02-09
通信作者: 马香 E-mail:maxiang0176@163.com
基金资助:
济南市卫健委科技计划项目(2022-2-163);济南市卫健委科技计划项目(2021-1-41);济南市卫健委科技计划项目(2020-4-89)

Research progress on the mechanism of there relationship between asthma and pertussisin children

Yan Jinyan¹, Li Xiaomin², Ma Xiang³()

¹Department of Infectious Diseases, Children’s Hospital Affiliated to Shandong University, Ji’nan 250022, China
²Department of Pediatrics,Maternal and Child Health Hospital, Dongchangfu District, Liaocheng 252000, China
³Department of Respiratory Diseases, Children’s Hospital Affiliated to Shandong University/Key Laboratory of Pediatric Respiratory Diseases, Ji’nan Children’s Hospital, Ji’nan 250022, China

Received:2022-08-23 Online:2023-02-20 Published:2023-02-09
Contact: Ma Xiang E-mail:maxiang0176@163.com
Supported by:
Science and Technology Plan Project of Ji’nan Municipal Health Commission(2022-2-163);Science and Technology Plan Project of Ji’nan Municipal Health Commission(2021-1-41);Science and Technology Plan Project of Ji’nan Municipal Health Commission(2020-4-89)

摘要/Abstract

摘要：

支气管哮喘是常见的慢性气道疾病,其主要病理机制为气道炎症及气道重塑,与多种呼吸道病原感染相关。由于近年来全球范围出现“百日咳重现”,百日咳与哮喘的关系也引起了学者们的广泛关注。大量的临床研究提示百日咳与哮喘之间具有相关性,但其相关机制尚未明确。作者对两者之间的相关机制研究在分子、细胞和组织水平进行了综述。在分子水平,百日咳感染可以导致气道炎症及气道重塑。在细胞水平,百日咳感染后可通过百日咳毒素诱导细胞骨架重组,丧失细胞连接的完整性,引发气道炎症,促进气道重塑。在组织水平,百日咳毒素和气管细胞毒素均可引起明显的呼吸道组织学改变,包括气管细胞毒素对纤毛呼吸上皮的挤压和破坏,导致气道炎症及气道重塑。

关键词: 儿童, 百日咳, 哮喘

Abstract:

Bronchial asthma is a common chronic respiratory disease, and its main pathological mechanism is airway inflammation and airway remodeling, which is associated with a variety of respiratory pathogenic infections. In recent years, the relationship between pertussis and asthma has been paid more and more attention because of the recurrence of pertussis all over the world. The correlation between pertussis and asthma has been suggested by a large number of clinical studies, but the related mechanism is not yet clear. The molecular, cellular and tissue-level mechanisms involved in these two mechanisms are reviewed in this paper. Pertussis infection can cause airway inflammation and airway remodeling at the molecular level. After pertussis infection,pertussis toxin can induce cytoskeletal reorganization, and then lose the integrity of cell junctions, trigger airway inflammation, and promote airway remodeling, at the cellular level. Both pertussis toxin and tracheal cytotoxin can cause significant airway histological changes, including extrusion and destruction of ciliated respiratory epithelium by tracheal cytotoxin, leading to airway inflammation and airway remodeling.

Key words: Children, Asthma, Pneumonia

中图分类号:

闫金燕, 李小敏, 马香. 儿童哮喘与百日咳关系机制的研究进展[J]. 结核与肺部疾病杂志, 2023, 4(1): 78-84. doi: 10.19983/j.issn.2096-8493.20220136

Yan Jinyan, Li Xiaomin, Ma Xiang. Research progress on the mechanism of there relationship between asthma and pertussisin children[J]. Journal of Tuberculosis and Lung Disease, 2023, 4(1): 78-84. doi: 10.19983/j.issn.2096-8493.20220136

参考文献 80

[1]	中华医学会呼吸病学分会哮喘学组. 支气管哮喘防治指南(2020年版). 中华结核和呼吸杂志, 2020, 43(12):1023-1048. doi:10.3760/cma.j.cn112147-20200618-00721. doi: 10.3760/cma.j.cn112147-20200618-00721
[2]	Padem N, Saltoun C. Classification of asthma. Allergy Asthma Pro, 2019, 40(6):385-388. doi:10.2500/aap.2019.40.4253. doi: 10.2500/aap.2019.40.4253.
[3]	Jartti T, Bønnelykke K, Elenius V, et al. Role of viruses in asthma. Semin Immunopathol, 2020, 42(1):61-74. doi:10.1007/s00281-020-00781-5. doi: 10.1007/s00281-020-00781-5 pmid: 31989228
[4]	马香, 杨永弘. 呼吸道细菌感染与哮喘关系的研究进展. 国际呼吸杂志, 2012(20):1587-1590. doi:10.3760/cma.j.issn.1673-436x.2012.020.016. doi: 10.3760/cma.j.issn.1673-436x.2012.020.016.
[5]	中华预防医学会, 中华预防医学会疫苗与免疫分会. 中国百日咳行动计划专家共识. 中华预防医学杂志, 2021, 55(6):709-719. doi:10.3760/cma.j.cn112150-20210308-00230. doi: 10.3760/cma.j.cn112150-20210308-00230.
[6]	滕瑞红, 付丽, 柳俊芳, 等. 儿童咳嗽变异性哮喘误诊原因分析. 临床误诊误治, 2020, 33(7):1-4. doi:10.3969/j.issn.1002-3429.2020.07.001. doi: 10.3969/j.issn.1002-3429.2020.07.001.
[7]	Chen S, Wang Y, Li A, et al. Etiologies of Hospitalized Acute Bronchiolitis in Children 2 Years of Age and Younger:A 3 Years’Study During a Pertussis Epidemic. Front Pediatr, 2021, 9:621381. doi:10.3389/fped.2021.621381. doi: 10.3389/fped.2021.621381. URL
[8]	Wang G, Han D, Jiang Z, et al. Association between early bronchiolitis and the development of childhood asthma:a meta-analysis. BMJ Open, 2021, 11(5):e043956. doi:10.1136/bmjopen-2020-043956. doi: 10.1136/bmjopen-2020-043956.
[9]	Jartti T, Mäkelä MJ, Vanto T, et al. The link between bronchiolitis and asthma. Infect Dis Clin North Am, 2005, 19(3):667-689. doi:10.1016/j.idc.2005.05.010. doi: 10.1016/j.idc.2005.05.010. URL
[10]	郏继航, 郭琴, 万朝敏. 百日咳再现与疫苗策略研究进展. 中华儿科杂志, 2020, 58(8):686-689. doi:10.3760/cma.j.cn112140-20200116-00036. doi: 10.3760/cma.j.cn112140-20200116
[11]	刘艳芹, 于华凤, 马香. 百日咳再现及其应对措施的研究进展. 国际儿科学杂志, 2020, 47(2):5-7.doi:10.3760/cma.j.issn.1673-4408.2020.02.005. doi: 10.3760/cma.j.issn.1673-4408.2020.02.005.
[12]	Hellenbrand W, Beier D, Jensen E, et al. The epidemiology of pertussis in Germany:pastandpresent. BMC Infect Dis, 2009, 9:22. doi:10.1186/1471-2334-9-22. doi: 10.1186/1471-2334-9-22 pmid: 19243604
[13]	Juretzko P, Fabian Marx T, Haastert B, et al. Pertussis in Germany:Regional differences in management and vaccination status of hospitalize dcases. Epidemio Infect, 2001, 127(1):63-71. doi:10.1017/s0950268801005593. doi: 10.1017/s0950268801005593.
[14]	Nicolai T, Bellach B, Mutius EV, et al. Increased prevalence of sensitization against aeroallergens in adults in West compared with East Germany. Clin Exp Allergy, 1997, 27(8):886-892. pmid: 9291284
[15]	Rubin K, Glazer S. The pertussis hypothesis: Bordetella pertussis colonization in the etiology of asthma and diseases of Allergic sensitization. Med Hypotheses, 2018, 120:101-115. doi:10.1016/j.mehy.2018.08.006. doi: S0306-9877(18)30668-6 pmid: 30220328
[16]	谢甜, 钟礼立, 黄寒, 等. 225例支气管哮喘急性发作患儿呼吸道病原体检出及临床特征分析. 中国当代儿科杂志, 2020, 22(11):1198-1203. doi:10.7499/j.issn.1008-8830.2006024. doi: 10.7499/j.issn.1008-8830.2006024.
[17]	孟庆红, 丁明杰, 史伟, 等. 肺炎或哮喘住院患儿百日咳感染状况的血清学调查. 贵州医科大学学报, 2017, 42(11):1292-1296. doi:10.19367/j.Cnki.1000-2707.2017.11.012. doi: 10.19367/j.Cnki.1000-2707.2017.11.012.
[18]	Burgess JA, Abramson MJ, Gurrin LC, et al. Childhood infections and the risk of asthma: a longitudinal study over 37 years. Chest, 2012, 142(3): 647-654. doi:10.1378/chest.11-1432. doi: S0012-3692(12)60508-X pmid: 22459783
[19]	Nagel G, Weinmayr G, Flohr C, et al. Association of pertussis and measles infections and immunizations with asthma and allergic sensitization in ISAAC Phase Two. Pediatr Allergy Immunol, 2012, 23(8): 737-746. doi:10.1111/pai.12007. doi: 10.1111/pai.12007.
[20]	Kendirli SG, Yilmaz M, Bayram I, et al. Potential association between allergic diseases and pertussis infection in schoolchildren: results of two cross-sectional studies seven years apart. Allergol Immunopathol (Madr), 2009, 37(1):21-25. doi:10.1016/s0301-0546(09)70247-2. doi: 10.1016/s0301-0546(09)70247-2. URL
[21]	杨霞, 李超乾. 哮喘的免疫学机制及应用草分支杆菌治疗的进展. 实用医学杂志, 2017, 33(12):2064-2066. doi:10.3969/j.issn.1006-5725.2017.12.047. doi: 10.3969/j.issn.1006-5725.2017.12.047.
[22]	Hammad H, Lambrecht BN. The basic immunology of asthma. Cell, 2021, 184(6):1469-1485. doi:10.1016/j.cell.2021.02.016. doi: 10.1016/j.cell.2021.02.016 pmid: 33711259
[23]	Scanlon K, Skerry C, Carbonetti N. Association of pertussis toxin with severe pertussis disease. Toxins, 2019, 11(7): 373. doi:10.3390/toxins11070373. doi: 10.3390/toxins11070373. URL
[24]	Forghani H, Jamshidi Makiani M, Zarei Jaliani H, et al. Toward an Alum Free Mono-Component Monovalent Pertussis Vaccine: A Cytokine Response Assay. Iran J Immunol, 2020, 17(2): 111-120. doi:10.22034/iji.2020.86199.1749. doi: 10.22034/iji.2020.86199.1749 pmid: 32602465
[25]	刘苗, 马香. 儿童百日咳与支气管哮喘关系的研究进展. 国际呼吸杂志, 2021, 41(1):63-68. doi:10.3760/cma.j.cn131368-20200306-00129. doi: 10.3760/cma.j.cn131368-20200306-00129.
[26]	Massey O, Suphioglu C. Recent Advances in the Inhibition of the IL-4 Cytokine Pathway for the Treatment of Allergen-Induced Asthma. Int J Mol Sci, 2021, 22(24):13655. doi:10.3390/ijms222413655. doi: 10.3390/ijms222413655. URL
[27]	于华凤, 韩玉玲, 马香, 等. 儿童支气管哮喘血清IL-4、IL-10和IFN-γ浓度的测定及其临床意义. 中国实用医药, 2010, 33:13.
[28]	Manson ML, Säfholm J, James A, et al. IL-13 and IL-4, but not IL-5 nor IL-17A, induce hyperresponsiveness in isolated human small airways. J Allergy Clin Immunol, 2020, 145(3): 808-817. doi:10.1016/j.jaci.2019.10.037. doi: S0091-6749(19)31618-5 pmid: 31805312
[29]	Liu D, Tan Y, Bajinka O, et al. Th17/IL-17 Axis Regulated by Airway Microbes Get Involved in the Development of Asthma. Curr Allergy Asthma Rep, 2020, 20(4): 11. doi:10.1007/s11882-020-00903-x. doi: 10.1007/s11882-020-00903-x. URL
[30]	Kapil P, Merkel TJ. Pertussis vaccines and protective immunity. Curr Opin Immunol, 2019, 59:72-78. doi:10.1016/j.coi.2019.03.006. PMID:31078081. doi: S0952-7915(18)30123-7 pmid: 31078081
[31]	Warfel JM, Merkel TJ. Bordetella pertussis infection induces a mucosal IL-17 response and long-lived Thl7 and Thl immune memory cells in nonhuman primates. MucosalImmunol, 2012, 6(4):787-796. doi:10.1038/mi.2012.117. doi: 10.1038/mi.2012.117.
[32]	樊德利, 赵翊, 李伟. SP-A、TNF-α、IL-6、IL-8在支气管哮喘中的检测与分析. 中国卫生检验杂志, 2011, 21(2):450-451,453.
[33]	Borkner L, Curham LM, Wilk MM, et al. IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F⁺ neutrophils. Mucosal Immunol, 2021, 14(5):1183-1202. doi:10.1038/s41385-021-00407-5. doi: 10.1038/s41385-021-00407-5 pmid: 33976385
[34]	Mosley YY, Lu F, HogenEsch H. Differences in innate IFNγ and IL-17 responses to Bordetella pertussis between BALB/c and C57BL/6 mice: role of γδT cells, NK cells, and dendritic cells. Immunol Res, 2017, 65(6):1139-1149. doi:10.1007/s12026-017-8957-4. doi: 10.1007/s12026-017-8957-4. URL
[35]	Ramakrishnan RK, Al Heialy S, Hamid Q. Role of IL-17 in asthma pathogenesis and its implications for the clinic (Review). Expert Rev Respir Med, 2019, 13(11): 1057-1068. doi:10.1080/17476348.2019.1666002. doi: 10.1080/17476348.2019.1666002. URL
[36]	Gans MD, Gavrilova T. Understanding the immunology of asthma: Pathophysiology, biomarkers, and treatments for asthma endotypes. Paediatr Respir Rev, 2020, 36:118-127. doi:10.1016/j.prrv.2019.08.002. doi: 10.1016/j.prrv.2019.08.002 pmid: 31678040
[37]	Novosad J, Krčmová I. Evolution of our view on the IgE molecule role in bronchial asthma and the clinical effect of its modulation by omalizumab: Where do we stand today? Int J Immunopathol Pharmacol, 2020, 34:2058738420942386. doi:10.1177/2058738420942386. doi: 10.1177/2058738420942386.
[38]	Schuster A, Hofmann A, Reinhardt D. Does pertussis infection induce manifestation of allergy? Clin Investig, 1993, 71(3):208-213. doi:10.1007/BF00180103. doi: 10.1007/BF00180103.
[39]	严杰, 毛亚飞, 邵浙新. 百日咳鲍特菌外膜蛋白体外促肥大细胞脱颗粒的作用. 中华微生物学和免疫学杂志, 2004, 24(8):606-610.
[40]	Ennis DP, Cassidy JP, Mahon BP. Whole-cell pertussis vaccine protects against Bordetella pertussis exacerbation of allergic asthma. Immunol Lett, 2005, 97(1): 91-100. doi:10.1016/j.imlet.2004.10.011. doi: 10.1016/j.imlet.2004.10.011. pmid: 15626480
[41]	Bernsen RM, de Jongste JC, van der Wouden JC. Lower risk of atopic disorders in whole cell pertussis-vaccinated children. Eur Respir J, 2003, 22(6): 962-964. doi:10.1183/09031936.03.00039803. doi: 10.1183/09031936.03.00039803 pmid: 14680086
[42]	Aun MV, Almeida FM, Saraiva-Romanholo BM, et al. Diphteria-tetanus-pertussis vaccine reduces specific IgE, inflammation and remodelling in an animal model of mite-induced respiratory allergy. Vaccine, 2020, 38(1): 70-78. doi:10.1016/j.vaccine.2019.09.095. doi: S0264-410X(19)31338-6 pmid: 31630941
[43]	Mrozek-Budzyn D, Majewska R, Kieltyka A, et al. Whole-cell pertussis vaccine (DTwP) has no influence on allergic diseases and atopic sensitization in children. Postepy Dermatol Alergol, 2018, 35(4): 381-386. doi:10.5114/ada.2018.77668. doi: 10.5114/ada.2018.77668.
[44]	Sekiya K. Effects of Bordetella pertussis components on IgE and IgG1 responses. Microbiol Immunol, 1983, 27(11):905-915. doi:10.1111/j.13480421.1983.tb00656.x. doi: 10.1111/j.13480421.1983.tb00656.x. pmid: 6321910
[45]	Roth M, Zhong J, Zumkeller C, et al. The role of IgE-receptors in IgE-dependent airway smooth muscle cell remodelling. Plos One, 2013, 8(2): e56015. doi:10.1371/journal.pone.0056015. doi: 10.1371/journal.pone.0056015. URL
[46]	Matucci A, Vultaggio A, Maggi E, et al. Is IgE or eosinophils the key player in allergic asthma pathogenesis? Are we asking the right question? Respir Res, 2018, 19(1):113. doi:10.1186/s12931-018-0813-0. doi: 10.1186/s12931-018-0813-0. URL
[47]	Zhu M, Tian D, Li J, et al. Glycogen synthase kinase 3beta and beta-catenin are involved in the injury and repair of bronchial epithelial cellsinduced by scratching. Exp Mol Pathol, 2007, 83(1): 30-38. doi:10.1016/j.yexmp.2007.02.001. doi: 10.1016/j.yexmp.2007.02.001. URL
[48]	贾宵宵, 郑榕颖, 黄悦, 等. Wnt/β-catenin信号通路调控哮喘气道重塑的机制研究. 中国病理生理杂志, 2017, 33(9):1683-1689.doi:10.3969/j.issn.1000-4718.2017.09.024. doi: 10.3969/j.issn.1000-4718.2017.09.024.
[49]	Kilander MB, Dijksterhuis JP, Ganji RS, et al. WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins. Cell Signal, 2011, 23(3): 550-554. doi:10.1016/j.cellsig.2010.11.004. doi: 10.1016/j.cellsig.2010.11.004 pmid: 21070854
[50]	Halleskog C, Schulte G. Pertussis toxin-sensitive heterotrimericG (αi/o) proteinsmediate WNT/β-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A. Cell Signal, 2013, 25(4): 822-828. doi:10.1016/j.cellsig. 2012.12.006. doi: 10.1016/j.cellsig.2012.12.006 pmid: 23266471
[51]	Vanoni S, Scantamburlo G, Dossena S,et,al. Interleukin-Mediated Pendrin Transcriptional Regulation in Airway and Esophageal Epithelia. Int J Mol Sci, 2019, 20(3): 731. doi:10.3390/ijms20030731. doi: 10.3390/ijms20030731. URL
[52]	郭文婧, 邹映雪. 百日咳毒素的研究进展. 国际儿科学杂志, 2020, 47(5): 312-316. doi:10.3760/cma.j.issn.1673-4408.2020.05.004 doi: 10.3760/cma.j.issn.1673-4408.2020.05.004
[53]	Scanlon K, Skerry C, Carbonetti N. Role of MajorTox in Virulence Factors in Pertussis Infection and Disease Pathogenesis. Adv Exp Med Biol, 2019, 1183:35-51. doi:10.1007/5584_2019_403. doi: 10.1007/5584_2019_403 pmid: 31376138
[54]	Chen X, Wang K, Yao Q, et al. The relationship between the rs 4986791 variant of the TLR4 gene and the severity of bronchial asthma in children. Asian Pac J Allergy Immunol, 2021.10.12932/AP-100920-0954. doi:10.12932/AP-100920-0954. doi: 10.12932/AP-100920-0954.
[55]	Banus S, Stenger RM, Gremmer ER, et al. The role of Toll-like receptor-4 in pertussisvaccine-inducedimmunity. BMC Immunol, 2008, 9:21. doi: 10.1186/1471-2172-9-21 URL
[56]	Sinha S, Singh J, Jindal SK, et al. Roleof TLR4C>1196T(Thr399Ile) and TLR4A>896G(Asp299Gly) polymorphisms in a North Indian population withasthma:acase-controlstudy. Int J Immunogenet, 2014, 41(6):463-471. doi:10.1111/iji.12115. doi: 10.1111/iji.12115 pmid: 25331070
[57]	Wingler LM, Lefkowitz RJ. Conformational basis of G protein-coupled receptor signal ingversatility. Trends Cell Biol, 2020, 30(9):736-747. doi:10.1016/j.tcb.2020.06.002. doi: S0962-8924(20)30120-3 pmid: 32622699
[58]	Fuentes N, McCullough M, Panettieri RA Jr. RGS proteins, GRKs, and beta-arrestins modulate G protein-mediated signaling pathways in asthma. Pharmacol Ther, 2021, 223: 107818. doi:10.1016/j.pharmthera.2021.107818. doi: 10.1016/j.pharmthera.2021.107818. URL
[59]	Sharma P, Penn RB. Can GPCRs be targeted to control inflammation in asthma? Adv Exp Med Biol, 2021, 1304: 1-20. doi:10.1007/978-3-030-68748-9_1. doi: 10.1007/978-3-030-68748-9_1 pmid: 34019260
[60]	Paramonov VM, Sahlgren C, Rivero-Müller A, et al. iGIST-A Kinetic Bioassay for Pertussis Toxin Based on Its Effect on Inhibitory GPCR Signaling. ACS Sens, 2020, 5(11): 3438-3448. doi:10.1021/acssensors.0c01340. doi: 10.1021/acssensors.0c01340. URL
[61]	Garcia JG, Wang P, Schaphorst KL, et al. Critical involvement of p 38 MAP kinase in pertussis toxin-induced cytoskeletal reorganization and lung permeability. FASEB, 2002, 16(9): 1064-1076. doi:10.1096/fj.01-0895com. doi: 10.1096/fj.01-0895com. URL
[62]	Wilson R, Read R, Thomas M, et al. Effects of Bordetella pertussis infectionon human respiratory epithelium in vivo and in vitro. Infect Immun, 1991, 59(1):337-345. doi:10.1128/iai.59.1.337-345.1991. doi: 10.1128/iai.59.1.337-345.1991 pmid: 1987048
[63]	Soane MC, Jackson A, Maskell D, et al. Interaction of Bordetella pertussis with human respiratory mucosainvitro. Respir Med, 2000, 94(8):791-799. doi:10.1053/rmed.2000.0823. doi: 10.1053/rmed.2000.0823. URL
[64]	Angely C, Ladant D, Planus E, et al. Functional and structural consequences of epithelial cell invasion by Bordetella pertussis adenylate cyclase toxin. PLoS One, 2020, 15(5): e0228606. doi:10.1371/journal.pone.0228606. doi: 10.1371/journal.pone.0228606. URL
[65]	Banno A, Reddy AT, Lakshmi SP, et al. Bidirectional interaction of airway epithelial remodeling and inflammation in asthma. Clin Sci (Lond), 2020, 134(9): 1063-1079. doi:10.1042/CS20191309. doi: 10.1042/CS20191309 pmid: 32369100
[66]	Camargo LDN, Righetti RF, Aristóteles LRCRB, et al. Effects of Anti-IL-17 on Inflammation, Remodeling, and Oxidative Stress in an Experimental Model of Asthma Exacerbated by LPS. Front Immunol, 2018, 8: 1835. doi:10.3389/fimmu.2017.01835. doi: 10.3389/fimmu.2017.01835. URL
[67]	Hiramatsu Y, Suzuki K, Nishida T, et al. The Mechanism of Pertussis Cough Revealed by the Mouse-Coughing Model. mBio, 2022, 13(2): e0319721. doi:10.1128/mbio.03197-21. doi: 10.1128/mbio.03197-21.
[68]	Ricciardolo FLM, Folkerts G, Folino A, et al. Bradykinin in asthma: Modulation of airway inflammation and remodelling. Eur J Pharmacol, 2018, 827: 181-188. doi:10.1016/j.ejphar.2018.03.017. doi: S0014-2999(18)30164-X pmid: 29548973
[69]	Kessie DK, Lodes N, Oberwinkler H, et al. Activity of trachealcytotoxin of Bordetella pertussis in a human tracheobronchial 3D tissuemodel. Front Cell Infect Microbiol, 2021, 10: 614994. doi:10.3389/fcimb.2020.614994. doi: 10.3389/fcimb.2020.614994. URL
[70]	Locht C, Antoine R. The History of Pertussis Toxin. Toxins, 2021, 13(9): 623. doi:10.3390/toxins13090623. doi: 10.3390/toxins13090623. URL
[71]	Hoonakker ME. In Vivo Models and In Vitro Assays for the Assessment of Pertussis Toxin Activity. Toxins (Basel), 2021, 13(8): 565. doi:10.3390/toxins13080565. doi: 10.3390/toxins13080565. URL
[72]	Banafea GH, Bakhashab S, Alshaibi HF, et al. The role of human mast cells in allergy and asthma. Bioengineered, 2022, 13(3):7049-7064. doi:10.1080/21655979.2022.2044278. doi: 10.1080/21655979.2022.2044278 pmid: 35266441
[73]	Connelly CE, Sun Y, Carbonetti NH. Pertussis toxin exacerbates and prolongs airway inflammatory responses during Bordetella pertussis infection. Infection And Immunity, 2012, 80(12): 4317-4332. doi:10.1128/IAI.00808-12. doi: 10.1128/IAI.00808-12 pmid: 23027529
[74]	Carbonetti NH, Artamonova GV, Mays RM, et al. Pertussis toxin plays an early role in respiratory tract colonization by Bordetella pertussis. Infect Immun, 2003, 71(11): 6358-6366. doi:10.1128/IAI.71.11.6358-6366.2003. doi: 10.1128/IAI.71.11.6358-6366.2003 pmid: 14573656
[75]	Andreasen C, Carbonetti NH. Pertussis toxin inhibits early chemokine production to delay neutrophil recruitment in response to Bordetella pertussis respiratory tract infection in mice. Infect Immun, 2008, 76(11): 5139-5148. doi:10.1128/IAI.00895-08. doi: 10.1128/IAI.00895-08 pmid: 18765723
[76]	Carbonetti NH, Artamonova GV, Van Rooijen N, et al. Pertussis toxin targets airway macrophages to promote Bordetella pertussis infection of the respiratory tract. Infect Immun, 2007, 75(4): 1713-1720. doi:10.1128/IAI.01578-06. doi: 10.1128/IAI.01578-06. pmid: 17242062
[77]	Carbonetti NH. Immunomodulation in the pathogenesis of Bordetella pertussis infection and disease. Curr Opin Pharmacol, 2007, 7(3):272-278. doi:10.1016/j.coph.2006.12.004. doi: 10.1016/j.coph.2006.12.004. pmid: 17418639
[78]	Ennis DP, Cassidy JP, Mahon BP. Prior Bordetella pertussis infection modulates allergen priming and the severity of airway pathology in a murine model of allergic asthma. Clin Exp Allergy, 2004, 34(9):1488-1497. doi:10.1111/j.1365-2222.2004.02042.x doi: 10.1111/j.1365-2222.2004.02042.x pmid: 15347385
[79]	Sundqwist M, Trollfors B, Taranger J. Pertussis in infancy does not increase the risk of asthma. Pediatrics, 1998, 102(6):1496-1497. doi:10.1542/peds.102.6.1496. doi: 10.1542/peds.102.6.1496. pmid: 9882235
[80]	Kugelman A, Anabussi S, Sharon N, et al. The association between pertussis during intancy and childhood asthma. Harefuah, 2009, 148(2):80-83,140-141. pmid: 19627033

儿童哮喘与百日咳关系机制的研究进展

Research progress on the mechanism of there relationship between asthma and pertussisin children

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献 80

相关文章 15

编辑推荐

Metrics

本文评价

友情链接

[1]	娄南南, 郭晶, 马香, 盖中涛. 咳嗽变异性哮喘病理机制及治疗的研究进展[J]. 结核与肺部疾病杂志, 2022, 3(6): 521-525.
[2]	陈豪, 申晨. 重视儿童结核病的鉴别诊断[J]. 结核与肺部疾病杂志, 2022, 3(5): 353-357.
[3]	胡亚红, 刘丹丹, 高薇, 孟庆红, 姚开虎. 胶体金法评估血清百日咳毒素抗体IgG水平的初步研究[J]. 结核与肺部疾病杂志, 2022, 3(5): 360-363.
[4]	李妍, 韩彤昕, 朴玉蓉, 毛华伟. 儿童关节结核误诊为幼年特发性关节炎五例临床分析[J]. 结核与肺部疾病杂志, 2022, 3(5): 364-370.
[5]	郑惠文, 李飞娜, 申晨. 儿童耐药结核病诊治研究进展[J]. 结核与肺部疾病杂志, 2022, 3(5): 402-404.
[6]	张春华, 陈伟. 儿童结核病流行现状与经济负担研究进展[J]. 结核与肺部疾病杂志, 2022, 3(5): 405-409.
[7]	刘芳, 马渝燕, 饶小春, 孟辰芳, 潘跃娜, 焦安夏. 氩等离子凝固术联合冷冻治疗儿童淋巴结瘘型气管支气管结核一例[J]. 结核与肺部疾病杂志, 2022, 3(5): 425-428.
[8]	林慧敏, 符昱, 方章福, 谢佳星. 嗜酸性粒细胞哮喘的研究进展[J]. 结核与肺部疾病杂志, 2022, 3(4): 328-333.
[9]	石家云, 王曼知, 危松青, 张小佛, 符星, 张锋, 周海依. Ommaya囊植入术治疗儿童结核性脑膜炎合并急性颅内高压综合征三例[J]. 结核与肺部疾病杂志, 2022, 3(1): 75-79.
[10]	林慧敏, 谢佳星. 重症哮喘应用贝那利珠单抗治疗二例[J]. 结核与肺部疾病杂志, 2022, 3(1): 80-84.
[11]	孙闪华, 李艳圆, 陶荔莹, 高志东, 张红伟, 许琰, 陈曦. 2011—2020年北京市儿童肺结核报告登记及流行病学特征分析[J]. 结核与肺部疾病杂志, 2021, 2(4): 305-310.
[12]	郭倩, 申晨. 儿童非结核分枝杆菌病研究进展[J]. 结核与肺部疾病杂志, 2021, 2(2): 184-188.
[13]	周洁, 祁勍, 陈龙, 武蕊, 史光烁, 杜鹤, 刘亚欣, 熊雷, 吴志乐, 吴国霞. 内科医师对全球哮喘防治倡议知晓情况调查[J]. 结核与肺部疾病杂志, 2021, 2(2): 189-192.
[14]	焦伟伟. 儿童结核病分子生物学诊断方法研究进展[J]. 结核与肺部疾病杂志, 2021, 2(1): 69-72.
[15]	热娜·阿卜来提, 克丽别娜·吐尔逊, 迪丽努尔·乌甫尔. 支气管哮喘与心理障碍相关性的研究进展[J]. 结核与肺部疾病杂志, 2020, 1(3): 285-288.