结核与肺部疾病杂志 ›› 2024, Vol. 5 ›› Issue (6): 583-589.doi: 10.19983/j.issn.2096-8493.2024131
孟婷1, 陈敬芳1,2(), 邓国防3, 林奕3, 阮淑金1, 刘琳琳4, 李孟君1
收稿日期:
2024-08-20
出版日期:
2024-12-20
发布日期:
2024-12-11
通信作者:
陈敬芳
E-mail:13823139640@163.com
基金资助:
Meng Ting1, Chen Jingfang1,2(), Deng Guofang3, Lin Yi3, Ruan Shujin1, Liu Linlin4, Li Mengjun1
Received:
2024-08-20
Online:
2024-12-20
Published:
2024-12-11
Contact:
Chen Jingfang
E-mail:13823139640@163.com
Supported by:
摘要:
结核病是由结核分枝杆菌引起的以肺部感染为主的慢性传染性疾病,其治疗周期一般为6个月,患者在抗结核治疗过程中易出现焦虑、抑郁状态,尤其是心理脆弱者,不仅会影响个体身心健康、精神状况及人际交往,还会降低其服药和治疗积极性和依从性,影响抗结核治疗结局。因此,本文就心理脆弱和焦虑抑郁的概念、发病情况、评估工具、影响因素及临床干预方法等方面进行综述,为临床医师开展结核病患者早期心理脆弱、焦虑抑郁筛查,并及时实施心理干预,降低结核病患者严重心理疾病的发生提供参考依据。
中图分类号:
孟婷, 陈敬芳, 邓国防, 林奕, 阮淑金, 刘琳琳, 李孟君. 结核病患者心理脆弱及焦虑抑郁状态相关研究进展[J]. 结核与肺部疾病杂志, 2024, 5(6): 583-589. doi: 10.19983/j.issn.2096-8493.2024131
Meng Ting, Chen Jingfang, Deng Guofang, Lin Yi, Ruan Shujin, Liu Linlin, Li Mengjun. Research progress on mental vulnerability and anxiety-depression status in tuberculosis patients[J]. Journal of Tuberculosis and Lung Disease, 2024, 5(6): 583-589. doi: 10.19983/j.issn.2096-8493.2024131
[1] |
Amaral AF, Coton S, Kato B, et al. Tuberculosis associates with both airflow obstruction and low lung function: BOLD results. Eur Respir J, 2015, 46(4):1104-1112. doi:10.1183/13993003.02325-2014.
pmid: 26113680 |
[2] |
Chen X, Du L, Wu R, et al. Tuberculosis-related stigma and its determinants in Dalian, Northeast China: a cross-sectional study. BMC Public Health, 2021, 21(1): 6. doi:10.1186/s12889-020-10055-2.
pmid: 33397334 |
[3] |
Alene KA, Clements ACA, McBryde ES, et al. Mental health disorders, social stressors, and health-related quality of life in patients with multidrug-resistant tuberculosis: A systematic review and meta-analysis. J Infect, 2018, 77(5):357-367. doi:10.1016/j.jinf.2018.07.007.
pmid: 30036607 |
[4] |
Koyanagi A, Vancampfort D, Carvalho AF, et al. Depression comorbid with tuberculosis and its impact on health status: cross-sectional analysis of community-based data from 48 low- and middle-income countries. BMC Med, 2017, 15(1): 209. doi:10.1186/s12916-017-0975-5.
pmid: 29179720 |
[5] | Mohammedhussein M, Alenko A, Tessema W, et al. Prevalence and Associated Factors of Depression and Anxiety Among Patients with Pulmonary Tuberculosis Attending Treatment at Public Health Facilities in Southwest Ethiopia. Neuropsychiatr Dis Treat, 2020, 16:1095-1104. doi:10.2147/NDT.S249431. |
[6] |
Kumpuangdee S, Roomruangwong C, Sophonphan J, et al. Prevalence of depression and anxiety in pulmonary tuberculosis patients and its association with unsuccessful treatment outcome: A prospective cohort study. Indian J Tuberc, 2023, 70(3):297-302. doi:10.1016/j.ijtb.2022.05.007.
pmid: 37562903 |
[7] |
Eplov LF, Jørgensen T, Birket-Smith M, et al. Mental vulnerability as a predictor of early mortality. Epidemiology, 2005, 16(2):226-232. doi:10.1097/01.ede.0000152904.95284.0f.
pmid: 15703538 |
[8] | Sequeira CADC, Barbosa ENM, Nogueira MJC, et al. Evaluation of the Psychometric Properties of the Mental Vulnerability Questionnaire in Undergraduate Students. Perspect Psychiatr Care, 2017, 53(4):243-250. doi:10.1111/ppc.12164. |
[9] | Jørgensen TSH, Wium-Andersen MK, Jørgensen MB, et al. The impact of mental vulnerability on the relationship between cardiovascular disease and depression. Eur Psychiatry, 2020, 63(1):e16. doi:10.1192/j.eurpsy.2020.20. |
[10] | Jess P, Jess T, Beck H, et al. Neuroticism in relation to recovery and persisting pain after laparoscopic cholecystectomy. Scand J Gastroenterol, 1998, 33(5):550-553. doi:10.1080/00365529850172151. |
[11] |
Nakaya N, Bidstrup PE, Eplov LF, et al. Mental vulnerability and survival after cancer. Epidemiology, 2009, 20(6):916-920. doi:10.1097/EDE.0b013e3181b5f3b0.
pmid: 19752732 |
[12] |
Eplov LF, Petersen J, Jørgensen T, et al. The Mental Vulnerability Questionnaire: a psychometric evaluation. Scand J Psychol, 2010, 51(6):548-554. doi:10.1111/j.1467-9450.2010.00834.x.
pmid: 20642738 |
[13] | 郭静, 王瑛, 宋玉萍, 等. 中文版心理脆弱性问卷初步修订及在社区居民中应用信效度分析. 中国公共卫生, 2019, 35(2): 129-133. doi:10.11847/zgggws1119908. |
[14] | 公雨欣, 刘堃, 扈娜, 等. 修正版心理脆弱量表汉化后的信效度评价. 现代预防医学, 2019, 46(4): 683-686. |
[15] | Levenstein S, Jacobsen RK, Rosenstock S, et al. Mental vulnerability, Helicobacter pylori, and incidence of hospital-diagnosed peptic ulcer over 28 years in a population-based cohort. Scand J Gastroenterol, 2017, 52(9):954-961. doi:10.1080/00365521.2017.1324897. |
[16] | 江佳隆, 李贤. 老年脑卒中病人心理脆弱现状及影响因素. 护理研究, 2021, 35(3): 387-390. doi:10.12102/j.issn.1009-6493.2021.03.003. |
[17] | 关永莲, 顾毅, 蒋影. 老年维持性血液透析病人心理脆弱现状及其与希望水平和社会影响的相关性. 护理研究, 2022, 36(22): 3977-3981. doi:10.12102/j.issn.1009-6493.2022.22.006. |
[18] | 黄楹, 江琦, 蒙粮广, 等. 结核病患者受歧视及产生病耻感的现状及研究进展. 中国防痨杂志, 2019, 41(4): 452-456. doi:10.3969/j.issn.1000-6621.2019.04.016. |
[19] | Yuan Y, Jin J, Bi X, et al. Gender-Specific Association Between Perceived Stigma Toward Tuberculosis and Accep-tance of Preventive Treatment Among College Students With Latent Tuberculosis Infection: Cross-Sectional Analysis. JMIR Public Health Surveill, 2023, 9:e43972. doi:10.2196/43972. |
[20] |
Østergaard D, Dalton SO, Bidstrup PE, et al. Mental vulnera-bility as a risk factor for depression: a prospective cohort study in Denmark. Int J Soc Psychiatry, 2012, 58(3):306-314. doi:10.1177/0020764010396409.
pmid: 21441278 |
[21] | Andersen BL, Lacchetti C, Ashing K, et al. Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update. J Clin Oncol, 2023, 41(18):3426-3453. doi:10.1200/JCO.23.00293. |
[22] |
Liu X, Haagsma J, Sijbrands E, et al. Anxiety and depression in diabetes care: longitudinal associations with health-related quality of life. Sci Rep, 2020, 10(1):8307. doi:10.1038/s41598-020-57647-x.
pmid: 32433470 |
[23] | Duko B, Bedaso A, Ayano G. The prevalence of depression among patients with tuberculosis: a systematic review and meta-analysis. Ann Gen Psychiatry, 2020, 19:30. doi:10.1186/s12991-020-00281-8. |
[24] | Sutar R, Majumdar A, Yadav V, et al. Anxiety, stress, and quality of life in patients with tuberculosis: A systematic review and meta-analysis. Ind Psychiatry J, 2024, 33(1):13-29. doi:10.4103/ipj.ipj_58_23. |
[25] |
Dasa TT, Roba AA, Weldegebreal F, et al. Prevalence and associated factors of depression among tuberculosis patients in Eastern Ethiopia. BMC Psychiatry, 2019, 19(1):82. doi:10.1186/s12888-019-2042-6.
pmid: 30823918 |
[26] |
Huque R, Elsey H, Fieroze F, et al. “Death is a better option than being treated like this”: a prevalence survey and qualitative study of depression among multi-drug resistant tuberculosis in-patients. BMC Public Health, 2020, 20(1):848. doi:10.1186/s12889-020-08986-x.
pmid: 32493337 |
[27] | Dos Santos AP, Lazzari TK, Silva DR. Health-Related Quality of Life, Depression and Anxiety in Hospitalized Patients with Tuberculosis. Tuberc Respir Dis (Seoul), 2017, 80(1):69-76. doi:10.4046/trd.2017.80.1.69. |
[28] | World Health Organization. Global tuberculosis report 2023. Geneva: World Health Organization, 2023. |
[29] |
Chen X, Wu R, Xu J, et al. Prevalence and associated factors of psychological distress in tuberculosis patients in Northeast China: a cross-sectional study. BMC Infect Dis, 2021, 21(1):563. doi:10.1186/s12879-021-06284-4.
pmid: 34118910 |
[30] | Wang XB, Li XL, Zhang Q, et al. A Survey of Anxiety and Depressive Symptoms in Pulmonary Tuberculosis Patients With and Without Tracheobronchial Tuberculosis. Front Psychiatry, 2018, 9:308. doi:10.3389/fpsyt.2018.00308. |
[31] | Dan-Ni Z, Guang-Min Z, Yu-Hua D, et al. Prevalence and risk factors of anxiety and depression in patients with multi-drug/rifampicin-resistant tuberculosis. Front Public Health, 2024, 12:1372389. doi:10.3389/fpubh.2024.1372389. |
[32] | Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand, 1983, 67(6):361-370. doi:10.1111/j.1600-0447.1983.tb09716.x. |
[33] | 郑磊磊, 王也玲, 李惠春. 医院焦虑抑郁量表在综合性医院中的应用. 上海精神医学, 2003, 15(5): 264-266. doi:10.3969/j.issn.1002-0829.2003.05.003. |
[34] |
Anye LC, Agbortabot Bissong ME, Njundah AL, et al. Depression, anxiety and medication adherence among tuberculosis patients attending treatment centres in Fako Division, Cameroon: cross-sectional study. BJPsych Open, 2023, 9(3):e65. doi:10.1192/bjo.2023.42.
pmid: 37051974 |
[35] | 付颖辉, 张庆, 杨雪, 等. 气管-支气管结核患者焦虑和抑郁的现状及其影响因素. 中国医科大学学报, 2019, 48(7): 633-637. doi:10.12007/j.issn.0258-4646.2019.07.013. |
[36] |
Zung WW. A Self-Rating Depression Scale. Arch Gen Psychiatry, 1965, 12:63-70. doi:10.1001/archpsyc.1965.01720310065008.
pmid: 14221692 |
[37] |
Zung WW. A rating instrument for anxiety disorders. Psychosomatics, 1971, 12(6):371-379. doi:10.1016/S0033-3182(71)71479-0.
pmid: 5172928 |
[38] | 刘贤臣, 唐茂芹, 彭秀桂, 等. 焦虑自评量表SAS的因子分析. 中国神经精神疾病杂志, 1995, 21(6):359-360. |
[39] | 刘贤臣, 戴郑生, 唐茂芹, 等. 抑郁自评量表(SDS)医学生测查结果的因子分析. 中国临床心理学杂志, 1994, 2(3):151-154. |
[40] | 王琳, 侯黎莉, 郭影, 等. 肺结核患者焦虑和抑郁状态及其影响因素. 国际护理学杂志, 2018, 37(20):2844-2849. doi:10.3760/cma.j.issn.1673-4351.2018.20.035. |
[41] | 陈曦, 赵瑶, 许琰, 等. 北京市肺结核患者抑郁和焦虑现况及其影响因素. 中华医学杂志, 2016, 96(34):2749-2753. doi:10.3760/cma.j.issn.0376-2491.2016.34.013. |
[42] | Shi XR, Wu WL, Li CY, et al. Study on the impact of comprehensive geriatric assessment on anxiety and depression in chronic obstructive pulmonary disease patients. World J Clin Cases, 2024, 12(20):4057-4064. doi:10.12998/wjcc.v12.i20.4057. |
[43] | 黄玲, 王颜, 王洪伟, 等. 宫颈癌中晚期患者心理痛苦程度现状及影响因素分析. 中国医药导报, 2021, 18(20):168-171. |
[44] | Ugarte-Gil C, Ruiz P, Zamudio C, et al. Association of major depressive episode with negative outcomes of tuberculosis treatment. PLoS One, 2013, 8(7):e69514. doi:10.1371/journal.pone.0069514. |
[45] | Yan S, Zhang S, Tong Y, et al. Nonadherence to Antituberculosis Medications: The Impact of Stigma and Depressive Symptoms. Am J Trop Med Hyg, 2018, 98(1):262-265. doi:10.4269/ajtmh.17-0383. |
[46] |
Peltzer K, Naidoo P, Matseke G, et al. Prevalence of psychological distress and associated factors in tuberculosis patients in public primary care clinics in South Africa. BMC Psychiatry, 2012, 12:89. doi:10.1186/1471-244X-12-89.
pmid: 22839597 |
[47] |
Theron G, Peter J, Zijenah L, et al. Psychological distress and its relationship with non-adherence to TB treatment: a multicentre study. BMC Infect Dis, 2015, 15:253. doi:10.1186/s12879-015-0964-2.
pmid: 26126655 |
[48] | Qiu L, Tong Y, Lu Z, et al. Depressive Symptoms Mediate the Associations of Stigma with Medication Adherence and Quality of Life in Tuberculosis Patients in China. Am J Trop Med Hyg, 2019, 100(1):31-36. doi:10.4269/ajtmh.18-0324. |
[49] | Ambaw F, Mayston R, Hanlon C, et al. Incidence of depression in people with newly diagnosed tuberculosis in Ethiopia: a cohort study. Glob Ment Health (Camb), 2020, 7:e1. doi:10.1017/gmh.2019.27. |
[50] |
Mainga T, Schaap A, Scherer N, et al. Prevalence of mental distress in adults with and without a history of tuberculosis in an urban Zambian community. Glob Ment Health (Camb), 2023, 10:e89. doi:10.1017/gmh.2023.83.
pmid: 38161750 |
[51] | Mandal A, Verma AK, Kar SK, et al. A cross-sectional study to determine the psychological distress among pulmonary tuberculosis patients during COVID-19 pandemic. Monaldi Arch Chest Dis, 2022, 93(1). doi:10.4081/monaldi.2022.2255. |
[52] | Ahmad N, Javaid A, Syed Sulaiman SA, et al. Effects of Multidrug Resistant Tuberculosis Treatment on Patients’ Health Related Quality of Life: Results from a Follow Up Study. PLoS One, 2016, 11(7):e0159560. doi:10.1371/journal.pone.0159560. |
[53] | Vo NX, Xuan Doan TB, Kha Vo DN, et al. Assessing quality of life for multidrug-resistant and extensively drug-resistant tuberculosis patients. J Pak Med Assoc, 2019, 69(Suppl 2)(6):S137-S157. |
[54] |
Srinivasan G, Chaturvedi D, Verma D, et al. Prevalence of depression and anxiety among drug resistant tuberculosis: A study in North India. Indian J Tuberc, 2021, 68(4):457-463. doi:10.1016/j.ijtb.2021.04.010.
pmid: 34752313 |
[55] |
Rajalakshmi M, Kalaiselvan G, Sudhakar R, et al. An explora-tory mixed method study on the follow up status and quality of life among recurrent tuberculosis patients in South India. Indian J Tuberc, 2020, 67(4):515-522. doi:10.1016/j.ijtb.2020.07.028.
pmid: 33077053 |
[56] | Caceres-Cardenas G, Ruiz-Grosso P, Ugarte-Gil C. Challenges in the management of depressive disorders comorbid with tuberculosis and type 2 diabetes. Curr Opin Psychiatry, 2023, 36(5):360-365. doi:10.1097/YCO.0000000000000885. |
[57] |
Kumar Panda U, Ra D, Swaroop Sahoo S, et al. Interplay between tuberculosis, mental illness, and treatment compliance: An integrative literature review. Indian J Tuberc, 2024, 71(3):353-357. doi:10.1016/j.ijtb.2023.10.004.
pmid: 39111946 |
[58] |
Pang Y, Liu R, Song Y, et al. High Incidence of Psychiatric Disorders Associated with Cycloserine Treatment of Multidrug-Resistant Tuberculosis Patients: A Cohort Study in Beijing, China. Infect Drug Resist, 2022, 15:3725-3732. doi:10.2147/IDR.S369715.
pmid: 35859910 |
[59] |
Hwang TJ, Wares DF, Jafarov A, et al. Safety of cycloserine and terizidone for the treatment of drug-resistant tuberculosis: a meta-analysis. Int J Tuberc Lung Dis, 2013, 17(10):1257-1266. doi:10.5588/ijtld.12.0863.
pmid: 23735593 |
[60] | Susanto TD, Widysanto A, Cipta DA, et al. Anxiety and depression level of patients with multidrug-resistant tuberculosis (MDR-TB) in two hospitals in Banten province, Indonesia. Dialogues Health, 2023, 2:100115. doi:10.1016/j.dialog.2023.100115. |
[61] | Tornheim JA, Udwadia ZF, Arora PR, et al. Cycloserine did not increase depression incidence or severity at standard dosing for multidrug-resistant tuberculosis. Eur Respir J, 2022, 59(3):2102511. doi:10.1183/13993003.02511-2021. |
[62] | 蔡穆, 黎永华. 肺结核患者心理健康状况及其影响因素调查分析. 中国卫生统计, 2018, 35(6): 913-915. |
[63] |
Assefa S, Boru B, Gebeyehu DA, et al. Depression, anxiety and their associated factors among patients with tuberculosis attending in Gondar city health facilities, North West Ethiopia. BMC Psychiatry, 2023, 23(1):91. doi:10.1186/s12888-023-04573-7.
pmid: 36747183 |
[64] | Wen S, Yin J, Sun Q. Impacts of social support on the treatment outcomes of drug-resistant tuberculosis: a systematic review and meta-analysis. BMJ Open, 2020, 10(10):e036985. doi:10.1136/bmjopen-2020-036985. |
[65] | 马志涛, 王娜, 吕阳, 等. 上海市宝山区肺结核患者心理状态及其影响因素分析. 中国防痨杂志, 2021, 43(4): 378-384. doi:10.3969/j.issn.1000-6621.2021.04.014. |
[66] | Fonseka N, Khan Z, Lewis M, et al. Cognitive therapy for depression in tuberculosis treatment: protocol for multicentre pragmatic parallel arm randomised control trial with an internal pilot. BMJ Open, 2024, 14(6):e083483. doi:10.1136/bmjopen-2023-083483. |
[67] | 童涌. 正念减压训练对肺结核患者焦虑抑郁情绪的影响. 中国现代医生, 2022, 60(15): 181-184. |
[68] | 任锐萍, 李亚琴, 杨艳霞, 等. 基于关怀服务模式的护理干预结合Orem自护模式对肺结核患者自尊水平、自护能力及病情控制的影响. 临床医学研究与实践, 2023, 8(19): 144-147. doi:10.19347/j.cnki.2096-1413.202319036. |
[69] | 陈轶韵, 魏秋梦, 张丽, 等. 延续性护理干预对肺结核患者遵医行为、生存质量和健康知识掌握情况的影响. 广州医科大学学报, 2024, 52(3): 60-63. doi:10.3969/j.issn.2095-9664.2024.03.11. |
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[4] | 赵永年, 张丽杰, 王童敏. 2014—2023年新疆生产建设兵团肺结核报告发病流行病学特征分析[J]. 结核与肺部疾病杂志, 2025, 6(1): 30-34. |
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