miR-451a调控TLR4信号通路在结核病发病中的研究进展

doi:10.19983/j.issn.2096-8493.2024097

摘要/Abstract

摘要：

微小RNA在免疫调节和炎症反应中发挥重要作用,参与多种疾病的发生发展过程。miR-451a作为一种微小RNA,在红细胞前体中大量表达,参与白血病等血液疾病的发生,同时也与先天性心脏病、食管癌、多发性骨髓瘤、脓毒症等疾病的病程相关。miR-451a能够调控TLR4信号通路,在结核病发病过程中发挥作用。笔者对miR-451a调控 TLR4信号通路的机制进行研究,旨在分析其在结核病发病中的研究进展,为研究抗结核药物靶点提供新的理论思路。

关键词: 微RNAs, 信号传导, 结核, 综述文献(主题)

Abstract:

MicroRNAs (miRNAs) play a pivotal role in immune regulation and inflammatory responses, contributing to the onset and progression of various diseases. miR-451a, a specific microRNA, is predominantly expressed in erythroid precursors and has been implicated in the pathogenesis of hematological disorders such as leukemia, as well as in non-hematological diseases including congenital heart disease, esophageal cancer, multiple myeloma, and sepsis. Furthermore, miR-451a modulates the TLR4 signaling pathway, thereby influencing the pathogenesis of tuberculosis. The authors investigated the mechanism by which miR-451a regulates the TLR4 signaling pathway, with the goal of examining recent advancements in understanding the role of miR-451a in tuberculosis pathogenesis. This study aims to provide novel theoretical insights for the identification of potential targets in anti-tuberculosis drug development.

Key words: MicroRNAs, Signal transduction, Tuberculosis, Review literature as topic

中图分类号:

赵菲, 詹璐. miR-451a调控TLR4信号通路在结核病发病中的研究进展[J]. 结核与肺部疾病杂志, 2024, 5(5): 484-488. doi: 10.19983/j.issn.2096-8493.2024097

Zhao Fei, Zhan Lu. Research progress on the regulation of TLR4 signaling pathway by miR-451a in the pathogenesis of tuberculosis[J]. Journal of Tuberculosis and Lung Disease, 2024, 5(5): 484-488. doi: 10.19983/j.issn.2096-8493.2024097

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