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Journal of Tuberculosis and Lung Disease ›› 2021, Vol. 2 ›› Issue (1): 69-72.doi: 10.3969/j.issn.2096-8493.2021.01.015

• Review Articles • Previous Articles     Next Articles

Advances in molecular diagnostic techniques of tuberculosis in children

JIAO Wei-wei()   

  1. MOE Key Laboratory of Major Diseases in Children, National Key Discipline of Pediatrics (Capital Medical University), National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University,Beijing 100045, China
  • Received:2021-02-22 Online:2021-03-30 Published:2021-03-24
  • Contact: JIAO Wei-wei E-mail:Jiaowei310@163.com

Abstract:

Tuberculosis is a major threat to children’s health. However, there are many difficulties in the diagnosis of tuberculosis in children. With the development of molecular biology technique, more and more new diagnostic methods for tuberculosis have emerged, including GeneXpert MTB/RIF, GeneXpert MTB/RIF ultra, metagenomic next-generation sequencing (mNGS) and methods based on isothermal amplification, as well as host based molecular diagnostic methods. This paper reviews the application of these methods in children.

Key words: Tuberculosis, Children, Molecular diagnostic techniques, Review literature as topic