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Journal of Tuberculosis and Lung Disease ›› 2021, Vol. 2 ›› Issue (1): 83-87.doi: 10.3969/j.issn.2096-8493.2021.01.018

• Review Articles • Previous Articles     Next Articles

Study progress on the application of sputum induction in the etiological diagnosis of pulmonary tuberculosis

HAN Mei1, HAN Pu2, CHEN Ya-ting3, YANG Song1(), YAN Xiao-feng1()   

  1. 1Research Institute of Tuberculosis, Chongqing Public Health Medical Center, Chongqing 400036, China
    2Department of Neurology, Chongqing Provincial Corps Hospital of the Chinese People’s Armed Police Force, Chongqing 400061, China
    3Obstetrics and Gynecology, the 909th Hospital of Joint Service Support Force of Chinese People’s Liberation Army, Fujian Province, Zhangzhou 363020, China
  • Received:2020-12-14 Online:2021-03-30 Published:2021-03-24
  • Contact: YANG Song,YAN Xiao-feng E-mail:yangsong5@aliyun.com;2429918342@qq.com

Abstract:

Sputum induction is recognized as a safe and non-invasive sampling method for collecting and analyzing airway cells, obtaining airway secretions from the patients with cystic fibrosis. It has been widely used for optimizing the examinations of various respiratory inflammatory diseases diagnosis, as well as for researching the inflammatory process and its mechanisms. Sputum induction has been demonstrated that it can achieve the similar positive rate to bronchoscope examination in tuberculosis (TB) diagnosis. The establishment of a standardized method of sputum induction has improved the quality of sputum sample. High quality sputum samples are helpful to improve the sensitivity of etiological detection of pulmonary TB, thus improving the positive rate of pulmonary TB diagnosis. The authors reviewed the current situation of sputum induction researches, as well as its clinical applications. They also compared the efficiency of different sputum induction methods in clinical applications, including hypertonic saline, lung flutters, physiotherapy sputum sample collection technology, and hypertonic saline plus physiotherapy sputum sample collection technology. The value of sputum induction method with hypertonic saline in etiological diagnosis of TB was in depth discussed in this paper.

Key words: Sputum, Tuberculosis, pulmonary, Diagnosis