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Journal of Tuberculosis and Lung Disease ›› 2024, Vol. 5 ›› Issue (2): 179-185.doi: 10.19983/j.issn.2096-8493.20230118

• Review Articles • Previous Articles    

Research progress on immune cells in chronic obstructive pulmonary disease complicated with cardiovascular disease

Peng Maocuo1, Xie Jungang2()   

  1. 1Department of Respiratory Medicine, Qinghai University Affiliated Hospital, Qinghai 810000, China
    2Department of Respiratory Medicine,Tongji Hospital,Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • Received:2023-09-27 Online:2024-04-20 Published:2024-04-11
  • Contact: Xie Jungang


In addition to impaired lung structure and function, chronic obstructive pulmonary disease (COPD) has the release of local inflammatory mediators into circulation system which would induce a systemic inflammatory response. The systemic inflammatory response can further cause or exacerbate extra-pulmonary comorbidities of COPD, such as cardiovascular disease (CVD), osteoporosis, anxiety and depression, and infections, with CVD being particularly commonly observed in clinical practice. Patients with COPD are at an increased risk of CVD, and co-morbid CVD can lead to decreased quality of life, re-hospitalization, and a worse long term prognosis. COPD and CVD are the greatest global disease burden, and they both have immune cell malfunction. Therefore, knowing the common mechanisms of these two diseases could contribute to a comprehensive understanding and appropriate management of them, thereby alleviating the burden of disease. The authors provides an overview of the immune mechanisms of COPD and CVD.

Key words: Pulmonary disease,chronic obstructive cardiovascular disease, Cardiovascular disease, Immunity, Review literature as topic

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