Progress in the expression of long-stranded noncoding RNA and their role in chronic obstructive pulmonary disease

doi:10.19983/j.issn.2096-8493.20240040

Abstract

Abstract:

Chronic obstructive pulmonary disease (COPD) is a kind of preventable and treatable chronic lung disease characterized by persistent respiratory symptoms and airflow limitation. Long non-coding RNA (lncRNA) is a class of transcription products with long nucleotide chains that exert a variety of biological effects by regulating the expression of related molecules in various forms. In recent years, it has been demonstrated that lncRNA can be involved in the pathological response of COPD by regulating various molecular biological processes such as inflammatory response, oxidative stress and apoptosis, and have gradually become an important target for the diagnosis and treatment of COPD. In this paper, we reviewed the research progress of lncRNA expression in COPD, oxidative stress, human pulmonary microvascular endothelial cells apoptosis, and their role in pathological mechanisms, with the aim of providing new ideas and directions for the diagnosis and efficacy assessment of COPD.

Key words: Pulmonary disease, chronic obstructive, RNA, Pathologic processes, Review literature as topic

CLC Number:

R563
R392

Yan Yanfeng, Qi Wenxia, Cui Yonghui, Wei Caihong. Progress in the expression of long-stranded noncoding RNA and their role in chronic obstructive pulmonary disease[J]. Journal of Tuberculosis and Lung Disease , 2024, 5(2): 172-178. doi: 10.19983/j.issn.2096-8493.20240040

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