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Journal of Tuberculosis and Lung Disease ›› 2023, Vol. 4 ›› Issue (2): 153-157.doi: 10.19983/j.issn.2096-8493.20230021

• Review Articles • Previous Articles     Next Articles

Research progress of targeting bronchial epithelium in asthma

Huang Junwen, Chen Ying, Cai Shaoxi, Zhao Haijin()   

  1. Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  • Received:2023-01-16 Online:2023-04-20 Published:2023-04-07
  • Contact: Zhao Haijin, Email:
  • Supported by:
    National Natural Science Foundation of China(81900027);National Natural Science Foundation of China(82070030);Natural Science Foundation of Guangdong Province(2022A1515012064);Natural Science Foundation of Guangdong Province(2023A1515010406)


Asthma is a heterogeneous disease affected by both heredity and environment. Airway epithelial injury is a common pathological change in asthma. The physical barrier function and immunomodulatory function of airway epithelium cooperatively respond to the stimulation and post-injury repair of viruses, allergens and air pollutants, and play an important role in airway inflammation, airway hyper-responsiveness and airway remodeling. In recent years, targeted therapy for bronchial epithelium had shown clinical value and became a potential new intervention target for asthma, especially for severe asthma. This article will focus on the role of airway epithelium in the pathogenesis of asthma and the treatment strategy targeting the airway epithelium of asthma.

Key words: Asthma, Pathology, clinical, Epithelium, Review literature as topic

CLC Number: