Abstract:

Asthma is a heterogeneous disease affected by both heredity and environment. Airway epithelial injury is a common pathological change in asthma. The physical barrier function and immunomodulatory function of airway epithelium cooperatively respond to the stimulation and post-injury repair of viruses, allergens and air pollutants, and play an important role in airway inflammation, airway hyper-responsiveness and airway remodeling. In recent years, targeted therapy for bronchial epithelium had shown clinical value and became a potential new intervention target for asthma, especially for severe asthma. This article will focus on the role of airway epithelium in the pathogenesis of asthma and the treatment strategy targeting the airway epithelium of asthma.

Key words: Asthma, Pathology, clinical, Epithelium, Review literature as topic