Abstract:

Combined pulmonary fibrosis and emphysema (CPFE) is an underrecognized syndrome characterized by progressive deterioration of respiratory symptoms, with imaging findings of emphysema in the upper lobe and fibrosis in the lower lobe. Lung function is characterized by relative lung volume retention and gas diffusion capacity decreased. Pulmonary hypertension and lung cancer are common comorbidities and the prognosis is poor. Further understanding of CPFE disease is helpful to clinicians in the diagnosis and treatment of CPFE. Therefore, the authors summarized the research progress of CPFE in recent years, including epidemiology, pathogenesis and risk factors, clinical manifestations, lung function, imaging findings, diagnosis, treatment, complications and prognosis.

Key words: Pulmonary disease, Pulmonary fibrosis, Pulmonary emphysema, Review literature as topic