Programmed cell death and its research progress in chronic obstructive pulmonary disease

doi:10.19983/j.issn.2096-8493.20230092

Abstract

Abstract:

Chronic obstructive pulmonary disease (COPD) has caused a considerable economic and social burden. However, its underlying cellular and molecular biological mechanisms have not been fully understood. Studying the regulation of cell death is crucial for exploring the mechanisms of different phenotypes in COPD. Programmed cell death (PCD) is a process of cell death mediated by molecular programs regulated by specific genes, involving signaling cascades. It has unique biochemical, morphological, and immunological characteristics and plays an important role in maintaining cellular homeostasis. The common PCD patterns include cell apoptosis, autophagy, necrotic apoptosis, and pyroptosis, as well as ferroptosis discovered in recent years. There is a cross interaction between multiple PCD modes, which together affect the cell outcome. More and more studies have shown that PCD is closely related to the occurrence and development of COPD. Deeply understanding the relationship between different PCD modes and the pathogenesis of COPD and further exploring the interactions between various PCD modes are beneficial for achieving comprehensive intervention in COPD, which may provide new choices for the prevention and treatment of patients with COPD.

Key words: Immunoglobulins, Pulmonary disease, chronic obstructive, Consensus development conferences as topic

CLC Number:

Cui Yanan, Chen Yan. Programmed cell death and its research progress in chronic obstructive pulmonary disease[J]. Journal of Tuberculosis and Lung Disease , 2023, 4(5): 397-406. doi: 10.19983/j.issn.2096-8493.20230092

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