结核与肺部疾病杂志 ›› 2024, Vol. 5 ›› Issue (4): 352-357.doi: 10.19983/j.issn.2096-8493.2024053

• 综述 • 上一篇    下一篇

女性不孕症在行体外受精-胚胎移植前结核感染筛查及诊疗进展

李亚波1, 樊丽娟2, 孙秀利1, 缑良芝1, 任倍莹1, 师娟子2, 王芳3, 马晓玲4, 谢永宏5, 刘鑫1, 仵倩红6()   

  1. 1陕西省结核病防治院妇科,西安 710100
    2西北妇女儿童医院生殖科,西安 710061
    3兰州大学第二附属医院生殖中心,兰州 730030
    4兰州大学第一附属医院生殖中心,兰州 730000
    5空军军医大学呼吸内科,西安 710032
    6陕西省第二人民医院(陕西省老年病医院)老年医学科,西安 710005
  • 收稿日期:2024-03-18 出版日期:2024-08-20 发布日期:2024-08-13
  • 通信作者: 仵倩红 E-mail:15902969531@126.com
  • 基金资助:
    西安市科学技术局西安市财政局基金(22YXYJ0160)

Progress in tuberculosis infection screening, diagnosis and treatment of female infertility patients before in vitro fertilization-embryo transfer

Li Yabo1, Fan Lijuan2, Sun Xiuli1, Gou Liangzhi1, Ren Beiying1, Shi Juanzi2, Wang Fang3, Ma Xiaoling4, Xie Yonghong5, Liu Xin1, Wu Qianhong6()   

  1. 1Department of Gynecology, Shaanxi Provincial Tuberculosis Prevention and Control Hospital, Xi’an 710100, China
    2Department of Reproduction, Northwest Women and Children’s Hospital, Xi’an 710061, China
    3Reproductive Center, the Second Affiliated Hospital of Lanzhou University, Lanzhou 730030, China
    4Reproductive Center, the First Affiliated Hospital of Lanzhou University, Lanzhou 730000, China
    5Department of Respiratory Medicine, Air Force Medical University, Xi’an 710032, China
    6Department of Geriatrics, the Second People’s Hospital of Shaanxi Province (Shaanxi Province Geriatric Hospital), Xi’an 710005, China
  • Received:2024-03-18 Online:2024-08-20 Published:2024-08-13
  • Contact: Wu Qianhong E-mail:15902969531@126.com
  • Supported by:
    Xi’an Science and Technology Bureau Xi’an Finance Bureau Fund(22YXYJ0160)

摘要:

女性生殖系统结核是女性不孕的常见因素,体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)是治疗女性不孕症的有效方法,女性生殖系统结核患者在进行IVE-ET过程中存在诱发结核活动和复发的风险,从而导致该部分人群IVF-ET成功率低,不良事件发生率高。中国结核病患者及结核分枝杆菌潜伏感染者基数大,不孕症女性进行IVF-ET前的结核感染筛查,以及采取必要的干预措施可以提高IVF-ET成功率,降低不良事件发生率。目前,国内外针对女性生殖系统结核感染的不孕症女性行IVE-ET前的规范处置尚无定论,笔者通过介绍实验室检查、影像学检查、内镜检查、病理组织检查、抗结核治疗在不孕症女性生殖系统结核感染的筛查、诊断、治疗过程中的应用进行综述,为不孕症女性在IVF-ET前的结核感染筛查及诊疗提供临床参考。

关键词: 结核, 受精, 体外, 胚胎移植, 诊断, 治疗学

Abstract:

In vitro fertilization-embryo transfer (IVF-ET) is an effective method for treating female infertility. During IVE-ET course, patients with female reproductive system tuberculosis have certain risk of activating tuberculosis to recurrent, which leads to low success rate of IVF-ET and high incidence of adverse events. In China, large number of patients have active tuberculosis disease or tuberculosis latent infection. Screening for tuberculosis infection before IVF-ET in infertile women and then taking necessary intervention can improve the success rate of IVF-ET and reduce the incidence of adverse events. At present, there is no conclusion on standard treatment before IVE-ET for infertile women with female reproductive system tuberculosis infection. This article reviews the application of laboratory, imaging, endoscopic, and pathological examination and anti-tuberculosis treatment in screening, diagnosis and treatment of female reproductive system tuberculosis infection, in order to provide clinical reference for the screening and treatment of tuberculosis infection in infertile women before IVF-ET.

Key words: Tuberculosis, Fertilization in vitro, Embryo transfer, Diagnosis, Therapeutics

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