机体抗结核分枝杆菌感染的主要免疫细胞及其作用机制

doi:10.3969/j.issn.2096-8493.2020.01.015

摘要/Abstract

摘要：

结核分枝杆菌是一种胞内寄生菌,细胞免疫在机体对结核分枝杆菌的免疫过程中发挥关键作用。巨噬细胞、自然杀伤细胞等是抵御这种病原体的早期防御细胞,适应性免疫细胞CD4⁺和CD8⁺ T 淋巴细胞在机体抗菌过程中发挥重要作用。但结核分枝杆菌的“免疫逃避”机制使其可以在宿主体内持续存在。作者概述了结核免疫过程中主要的免疫细胞及其作用机制,探讨了结核分枝杆菌免疫逃避现象,以期为开发新的预防治疗措施提供参考。

关键词: 分枝杆菌, 结核, 免疫, 免疫逃避, 疫苗, 防御机制, 综述

Abstract:

Mycobacterium tuberculosis (MTB) is a kind of intracellular parasitic bacterium. Cellular immunity plays a key role in the body’s immune process against MTB infection. Macrophages and natural killer (NK) cells are the early defense cells against this pathogen, and the adaptive immune cells, CD4⁺ and CD8⁺ T-cells, play an important role in the process against bacteria. However, the “immune escape” mechanism of MTB allows it to persist in the host. In this paper, the main immune cells and their immunity mechanisms in the process of TB immunity were summarized, and the immune evasion of MTB were discussed, so as to offer references for developing new preventive and therapeutic measures.

Key words: Mycobacterium tuberculosis, Immunity, Immune evasion, Vaccines, Defense mechanisms, Review

胡晓光, 陈灿灿, 张亚男, 马俊扬, 陈伟. 机体抗结核分枝杆菌感染的主要免疫细胞及其作用机制[J]. 结核与肺部疾病杂志, 2020, 1(1): 71-77. doi: 10.3969/j.issn.2096-8493.2020.01.015

HU Xiao-guang, CHEN Can-can, ZHANG Ya-nan, MA Jun-yang, CHEN Wei. The main immune cells against Mycobacterium tuberculosis infection and their mechanisms[J]. Journal of Tuberculosis and Lung Disease, 2020, 1(1): 71-77. doi: 10.3969/j.issn.2096-8493.2020.01.015

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