细胞焦亡与非小细胞肺癌转移相关性的研究进展

doi:10.19983/j.issn.2096-8493.2024082

摘要/Abstract

摘要：

随着非小细胞肺癌发病率及病亡率的增加,如何延缓疾病的进展并延长患者的生存期成为现在研究的重点和难点。转移是肿瘤发展过程中不可避免的环节,并显著影响患者的中位生存期。因此,预测转移的发生并进行预防性治疗是改善非小细胞肺癌患者预后的重要途径。有研究者关注到,细胞焦亡是一种可同时在正常组织与肿瘤细胞中表达的程序性细胞死亡方式,并在不同的肿瘤类型中表现出截然不同的生物学作用。本文概述了细胞焦亡的不同激活途径和应用价值,重点总结了细胞焦亡在非小细胞肺癌转移中发挥的双重作用,结合非小细胞肺癌脑转移的研究内容进行分析,认为细胞焦亡可能参与肿瘤的定向转移,以期为细胞焦亡与非小细胞肺癌转移之间的相关性研究提供新的思路。

关键词: 癌, 非小细胞肺, 肿瘤转移, 研究, 细胞焦亡

Abstract:

With the increasing incidence and mortality of non-small cell lung cancer (NSCLC), the focus and challenge of researches have been shifted towards delaying disease progression and prolonging patient survival. Metastasis is an inevitable aspect of tumor development which significantly affects patients’ median length of survival. Therefore, predicting metastasis occurrence and conducting preventive treatment are crucial for improving NSCLC prognosis. Some researchers have raised concerns about pyroptosis as a programmed cell death mode that can be expressed in both normal tissue and tumor cells, with distinctive biological effects in different types of tumor. This paper provides a summary of different activation pathways and application values of pyroptosis, focusing on its dual role in NSCLC metastasis. It suggests that pyroptosis may play an important role in targeted metastasis when considering current researches on brain metastasis of non-small cell lung cancer, offering a new approach to study the correlation between cell pyroptosis and NSCLC metastasis.

Key words: Carcinoma, non-small-cell lung, Neoplasm metastasis, Research, Pyroptosis

中图分类号:

R730.3

昌雨婷, 张欣然, 韩高华. 细胞焦亡与非小细胞肺癌转移相关性的研究进展[J]. 结核与肺部疾病杂志, 2024, 5(3): 260-266. doi: 10.19983/j.issn.2096-8493.2024082

Chang Yuting, Zhang Xinran, Han Gaohua. Research progress on the correlation between pyroptosis and metastasis of non-small cell lung cancer[J]. Journal of Tuberculosis and Lung Disease, 2024, 5(3): 260-266. doi: 10.19983/j.issn.2096-8493.2024082

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