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Journal of Tuberculosis and Lung Disease ›› 2023, Vol. 4 ›› Issue (2): 164-168.doi: 10.19983/j.issn.2096-8493.20230016

• Review Articles • Previous Articles     Next Articles

The role of ceramide and ceramide synthetase in asthma

Hu Tingting, Chang Chun()   

  1. Department of Respiratory and Critical Care Medicine, Third Hospital of Peking University, Beijing 100191, China
  • Received:2023-01-09 Online:2023-04-20 Published:2023-04-07
  • Contact: Chang Chun, Email:


Ceramide is the center of sphingolipids metabolism and is an important signal molecule participates in many biological functions such as cell differentiation, proliferation, apoptosis and migration. Synthesis is mediated by ceramide synthetase. Asthma is a chronic airway disease characterized by airflow obstruction, airway hyper-responsiveness and lung inflammation, which greatly affects the quality of life and is an important public health problem. Studies have shown that ceramides play an important role in the pathophysiological development of asthma. This article focuses on the effects of ceramides on various cells involved in the pathogenesis of asthma and the differences in the effects of different ceramides, to provide a theoretical basis for better understanding of asthma and finding potential therapeutic targets for asthma.

Key words: Asthma, Ceramides, Review literature as topic

CLC Number: