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Journal of Tuberculosis and Lung Disease ›› 2023, Vol. 4 ›› Issue (2): 158-163.doi: 10.19983/j.issn.2096-8493.20230036

• Review Articles • Previous Articles     Next Articles

Research progress of airway remodeling mechanism in asthma

Wang Zhongzhao, Tang Hao()   

  1. Department of Respiratory and Critical Care Medicine of Changzheng Hospital, Second Affiliated Hospital of Naval Military Medical University, Shanghai 200003, China
  • Received:2023-03-02 Online:2023-04-20 Published:2023-04-07
  • Contact: Tang Hao, Email:
  • Supported by:
    Shanghai Education Development Foundation and Shanghai Municipal Education Commission(20SG38);Shanghai Municipal Science and Technology Committee of Shanghai Outstanding Academic Leaders Plan(20XD1423300);General Program of National Nature Science Foundation of China(82070036)


Asthma is a global respiratory disease characterized by chronic inflammation in the airway and reversible airway restriction. Typical clinical symptoms of asthma are dyspnea, cough, chest tightness, and wheezing, etc. The airway remodeling and persistent airflow restriction in asthmatic patients may occur in the early stage of the disease, and is closely related to exacerbation of symptoms and medication. Therefore, early identification intervention may become an important way to treat asthma patients. High-resolution computed tomography (HRCT), as a non-invasive technique, is increasingly used to examine different aspects of airway remodeling in asthma. In this paper, the diagnosis airway remodeling in asthmatics by HRCT and the mechanism of airway remodeling in recent years were reviewed.

Key words: Airway obstruction, Asthma, Tomography, X-ray computed

CLC Number: