Clinical value of IFIT3 and PCT in prognosis evaluation of elderly patients with severe tuberculosis

doi:10.19983/j.issn.2096-8493.2024030

Abstract

Abstract:

Objective: To investigate the value of IFIT3 (interferon-induced protein with tetratricopeptide repeats 3,IFIT3) and procalcitonin (PCT) in the prognosis of elderly patients with severe pulmonary tuberculosis (PTB). Methods: In this prospective study, 82 elderly patients with severe PTB in the ICU of Hebei Chest Hospital from April 2022 to March 2023 were selected as study objects, and divided into survival group (42 cases) and death group (40 cases) according to the outcomes of the patients after they admitted to the ICU for 28 days. Clinical data of these two groups of patients were collected, and serum IFIT3 and PCT contents were determined by enzyme-linked immunosorbent assay (ELISA). The predictive value of IFIT3 and PCT on death was then analyzed by plotting receiver operating characteristic (ROC) curve, while the prognosis at 28 days after admission to ICU was used as the reference standard. Results: The acute physiology and chronic health status assessment system Ⅱ (APACHEⅡ) score, serum IFIT3 and PCT level of the elderly patients with severe PTB in the death group were 25.68±8.12, 21.00 (13.00, 48.00) pg/ml and 3.21 (0.96, 5.78) ng/ml, respectively, higher than those in the survival group (21.17±8.57, 11.00 (5.75, 22.75) pg/ml and 0.41 (0.15, 1.04) ng/ml). The differences were statistically significant (t=-2.373, P=0.018;Z=-2.920, P=0.003;Z=2.028, P=0.001). The area under ROC curve (AUC) of IFIT3 and PCT were 0.687 (95%CI:0.572-0.803) and 0.832 (95%CI:0.741-0.922) respectively for predicting death. When the optimal threshold value of IFIT3 was 12.50 pg/ml, the sensitivity and specificity of predicting death were 77.5% and 59.5%. When the optimal threshold of serum PCT was 1.44 ng/ml, the sensitivity and specificity of predicting death were 72.5% and 83.3%. AUC of combing IFIT3 with PCT in predicting death was 0.850 (95%CI: 0.767-0.933), the sensitivity and specificity were 75.0% and 83.3%, and the positive predictive value and negative predictive value were 81.1% and 75.6%. Conclusion: IFIT3 combined with PCT test has a certain clinical value in the prognosis assessment of elderly patients with severe PTB in ICU.

Key words: Interferon inducers, Intensive care units, Aged, Forecasting

CLC Number:

Wei Yunxia, Wang Xin, Long Xuejuan, Shao Lijiao, Yan Lijing, Yu Di, Li Ning. Clinical value of IFIT3 and PCT in prognosis evaluation of elderly patients with severe tuberculosis[J]. Journal of Tuberculosis and Lung Disease , 2024, 5(2): 143-147. doi: 10.19983/j.issn.2096-8493.2024030

Figures/Tables 2

指标	生存组(42例)	死亡组(40例)	统计检验值	P值
年龄[岁,M(Q₁, Q₃)]	69.00(63.00,76.25)	66(60.00,74.00)	Z=-0.916	0.360
性别[例,构成比(%)]			χ²=1.334	0.342
男性	34(80.95)	29(72.50)
女性	8(19.05)	11(27.50)
BMI( $x ˉ$ ±s)	22.16±4.19	20.08±3.91	t=-2.157	0.031
WBC[×10⁹/L,M(Q₁, Q₃)]	9.25(6.08,14.30)	9.99(5.91,14.50)	Z=-0.232	0.817
Hb(g/L, $x ˉ$ ±s)	107.98±24.23	97.75±21.44	t=-1.759	0.079
D二聚体[ng/L,M(Q₁, Q₃)]	2.74(1.55,5.04)	4.46(2.01,6.95)	Z=-1.726	0.084
CRP [mg/L,M(Q₁, Q₃)]	71.40(41.20,128.90)	139.90(75.50,120.00)	Z=-2.301	0.021
OI [mmHg,M(Q₁, Q₃)]	118.00(97.50,189.00)	105.00(91.00,135.50)	Z=-1.838	0.066
APACHEⅡ (分, $x ˉ$ ±s)	21.17±8.57	25.68±8.12	t=-2.373	0.018

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