Abstract:

Objective To investigate the prognostic value of the combined detection of serum procalcitonin (PCT), hypersensitive c-reactive protein (hs-CRP) and d-dimer (D-D) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods The medical records of 87 AECOPD patients who admitted to the Respiratory Department of Qingyuan Chronic Disease Prevention and Control Hospital, Guangdong Province from July 2017 to February 2019 were retrospectively analyzed. The patients were divided into the survival group (65 cases) and the death group (22 cases) according to the prognosis. The serum PCT expression was detected by immunolatex turbidimetry; the serum D-D expression was detected by immunoturbidimetry; and the serum hs-CRP expression was measured by dry immunofluorescence assay. Receiver operating characteristic (ROC) curve was used to analyze the value of single and combined detection for predicting the prognosis of AECOPD patients.Results The expression levels of PCT, hs-CRP and D-D in the death group were (11.63±2.51) μg/L, (31.84±6.42) mg/L, and (6.70±2.13) mg/L respectively, which were significantly higher than those in the survival group ((5.72±1.24) μg/L, (17.57±4.36) mg/L, and (3.35±1.08) mg/L, respectively). The differences were statistically significant (t values: 14.53, 11.69 and 9.61, respectively; all P values <0.01). The sensitivity, specificity, accuracy and AUC of the combined detection of serum PCT, hs-CRP and D-D to predict the prognosis of AECOPD patients were 90.77%, 90.90%, 90.80% and 0.917, respectively.Conclusion The combined detection of serum PCT, hs-CRP and D-D has a high clinical value in predicting the prognosis of AECOPD patients.

Key words: Pulmonary disease,chronic obstructive, Disease progression, Calcitonin, C-reactive protein, ROC curve, Forecasting, Prognosis