结核病与肺部健康杂志 ›› 2012, Vol. 1 ›› Issue (2): 91-96.

• 论著 •    下一篇

以人群为基础的吸烟与肺癌死亡关系的病例对照研究

王德征,张辉,张颖,江国虹   

  1. 300011天津市疾病预防控制中心非传染病预防控制所
  • 收稿日期:2012-06-25 出版日期:2012-10-20 发布日期:2012-10-20
  • 通信作者: 江国虹,Email:jiangguohong@263.net

The relationship between smoking and lung cancer deaths:a population based case control study

WANG De-zheng,ZHANG Hui,ZHANG Ying,JIANG Guo-hong   

  1. Non-Communicable Disease Control and Prevention,Tianjin Centers for Disease Control and Prevention,Tianjin 300011,China
  • Received:2012-06-25 Online:2012-10-20 Published:2012-10-20
  • Contact: JIANG Guo-hong,Email:jiangguohong@263.net

摘要: 目的 了解天津市人群肺癌死亡特征及吸烟等危险因素分布,为肺癌的预防控制提供依据。方法 采用2011年天津市疾病预防控制中心收集的天津市居民全死因监测数据,以所有肺癌死亡患者作为病例组(5746例),以所有非肺癌死亡患者作为对照组(59 625例),疾病分类采用《疾病和有关健康问题的国际统计分类》(ICD-10),采用SPSS 11.5软件进行单因素和多因素logistic回归分析。结果 天津市人群肺癌粗死亡率为58.00/10万,标化死亡率为31.52/10万,肺癌为所有恶性肿瘤死亡中的首位死因(38.25%,5746/15 023),男性肺癌死亡率高于女性(分别为66.91/10万,48.99/10万;χ2=14.98,P=0.000)。单因素非条件logistic回归分析结果显示:男性(Wald χ2=6.09,P=0.014)、年龄增加(Wald χ2=755.19,P=0.000)、已婚状态(Wald χ2=348.24,P=0.000)、文化程度越低(Wald χ2=326.21,P=0.000)、城市地区(Wald χ2=291.08,P=0.000)、现在吸烟或已戒烟(Wald χ2=1388.41,P=0.000)、每日吸烟支数多(Wald χ2=289.43,P=0.000)、吸烟年限长(Wald χ2=185.07,P=0.000)是肺癌死亡可能的危险因素。多因素非条件logistic回归分析结果显示,现在和既往吸烟(Wald χ2=5.37,P=0.021;β=0.11;OR=1.12;95%CI=1.02~1.23)、每天吸烟支数多(Wald χ2=90.24,P=0.000;β=0.34;OR=1.41;95%CI=1.31~1.51)和吸烟年限长(Wald χ2=175.21,P=0.000;β=0.32;OR=1.38;95%CI=1.32~1.45)是肺癌死亡的独立危险因素;已婚状态(Wald χ2=89.42,P=0.000;β=0.22;OR=0.80;95%CI=0.77~0.84)、女性(Wald χ2=189.36,P=0.000;β=0.68;OR=1.98;95%CI=1.80~2.19)、城市地区(Wald χ2=70.61,P=0.000;β=0.40;OR=0.67;95%CI=0.61~0.74)、文化程度低(Wald χ2=42.40,P=0.000;β=0.19;OR=1.21;95%CI=1.14~1.28)是肺癌死亡的独立危险因素。结论 肺癌已成为危害天津市居民死亡的主要恶性肿瘤,吸烟与肺癌死亡密切相关,有必要开展控烟立法、开展肺癌危险因素知识健康教育,降低肺癌死亡危险。

Abstract: Objective The purpose of this study is to explore the distribution characteristics of lung cancer death and cigarette smoking, provide basis for prevention and control of lung cancer in Tianjin.Methods The study used data from the all-cause mortality surveillance system collected by the Tianjin Centers for Disease Control and Prevention (CDC). All death caused by lung cancer were classified in case group (5746 cases), and death caused by non-lung cancer (59 625 cases) as control group. Each lung cancer death in 2011 was coded using the International Classification of Diseases (ICD-10). Both single factors and multiple factors unconditional logistic regression ana-lysis was made by SPSS software version 11.5.Results The crude death rate of lung cancer in Tianjin was 58.00/100 000, with the standardized mortality rate of 31.52/100 000. Lung cancer is the leading cause of death (38.25%,5746/15 023) in all malignant tumors. Male had a higher lung cancer mortality than female(66.91/100 000 vs. 48.99/100 000, χ2=14.98,P=0.000). The single factor non-conditional logistic regression analysis showed that male(Wald χ2=6.09,P=0.014);age(Wald χ2=755.19,P=0.000);married status(Wald χ2=348.24,P=0.000);lower education(Wald χ2=326.21,P=0.000);living in urban areas(Wald χ2=291.08,P=0.000);current or former smokers(Wald χ2=1388.41,P=0.000); more number of cigarettes smoked daily(Wald χ2=289.43,P=0.000);more years of smoking(Wald χ2=185.07,P=0.000)are possible risk factors for lung cancer death. The multi-factor non-conditional logistic regression analysis showed that risk factors of lung cancer mortality were current or former smokers(Wald χ2=5.37,P=0.021;β=0.11;OR=1.12;95%CI=1.02-1.23), more number of cigarettes smoked daily(Wald χ2=90.24,P=0.000;β=0.34;OR=1.41;95%CI=1.31-1.51), more years of smoking(Wald χ2=175.21,P=0.000;β=0.32;OR=1.38;95%CI=1.32-1.45), the married status(Wald χ2=89.42,P=0.000;β=0.22;OR=0.80;95%CI=0.77-0.84), female (Wald χ2=189.36,P=0.000;β=0.68;OR=1.98;95%CI=1.80-2.19), living in urban areas (Wald χ2=70.61,P=0.000;β=0.40;OR=0.67;95%CI=0.61-0.74),lower education level(Wald χ2=42.40,P=0.000;β=0.19;OR=1.21;95%CI=1.14-1.28)are independent risk factors of lung cancer deaths.Conclusion Lung cancer death has become one of the main malignant tumors endangered the health of Tianjin residents. Smoking and lung cancer death is closely related. Therefore, there is the need to develop smoking free law and carry out heath education in order to reduce the mortality of lung cancer.