Abstract: Granulomatous polyangiitis is a kind of autoimmune diseases with varied clinical manifestations, which is easily confused with tuberculosis in imaging findings. In this paper, we collected the data of a case of gra-nulomatous polyangiitis with latent tuberculosis infection (LTBI). Through the discussion of the differential diagnosis, the value of T-SPOT.TB in diagnosing pulmonary tuberculosis was evaluated, and the ability of clinician’s diagnosis and differential diagnosis in granulomatous polyangiitis was improved.