结核病综合治疗研究进展

doi:10.19983/j.issn.2096-8493.20230112

摘要/Abstract

摘要：

结核病是由结核分枝杆菌复合群感染引起的慢性传染性疾病,尽管卡介苗和有效抗结核药物的成功问世使其有了有效的预防和治疗手段,但随着人口的不断流动、人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染、特殊疾病免疫抑制药物应用以及耐药结核病的不断出现等原因,特别是自2019年底出现的新型冠状病毒感染及流行,使结核病疫情控制至少倒退5~8年,彻底治愈结核病仍然挑战重重。而彻底治愈结核病患者仍然是阻断结核分枝杆菌传播、消除疾病传染的关键举措。在抗结核化疗的基础上,辅以外科手术治疗、介入治疗、免疫治疗、营养治疗、中医药治疗、心理治疗及康复治疗等综合治疗手段,有利于提高患者治愈率、降低不良反应等。临床医生需要综合评估患者的具体病情,有针对地选择个性化的综合治疗方案,从而获得最优的治疗效果。作者对近年来结核病综合治疗研究进展进行综述。

关键词: 结核, 分枝杆菌,结核, 抗药性,多药, 抗结核药

Abstract:

Tuberculosis is a chronic infectious disease caused by the infection of Mycobacterium tuberculosis complex. Although the success of BCG vaccine and effective anti-tuberculosis drugs has provided effective means of tuberculosis prevention and treatment, it is still quite challenging to cure tuberculosis completely with the continuous flow of population, and continuous emergence of HIV infection, usage of immunosuppressive drugs for special diseases and drug-resistant tuberculosis, especially for that the prevalence of COVID-19 since the end of 2019 has set back the epidemic control of tuberculosis for at least 5-8 years. Curing tuberculosis patients thoroughly is still the key measure to cut off the transmission of Mycobacterium tuberculosis and eliminate disease transmission. On the basis of anti-tuberculosis chemotherapy, combined with comprehensive treatment methods such as surgical treatment, interventional therapy, immunotherapy, nutritional therapy, traditional Chinese medicine treatment, psychological therapy, and rehabilitation therapy, it is beneficial to improve the patient’s cure rate and reduce adverse reactions. Clinicians need to comprehensively evaluate the specific condition of patients and choose individualized comprehensive treatment plans in a targeted manner to achieve the optimal treatment effect. This article reviews the research progress of tuberculosis comprehensive treatment in recent years.

Key words: Tuberculosis, Mycobacterium tuberculosis, Drug resistance,multiple, Antitubercular agents

中图分类号:

梁晨, 唐神结, 林明贵. 结核病综合治疗研究进展[J]. 结核与肺部疾病杂志, 2024, 5(1): 70-80. doi: 10.19983/j.issn.2096-8493.20230112

Liang Chen, Tang Shenjie, Lin Minggui. Research progress of comprehensive treatment for tuberculosis[J]. Journal of Tuberculosis and Lung Disease, 2024, 5(1): 70-80. doi: 10.19983/j.issn.2096-8493.20230112

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