Abstract: Objective To investigate the characteristics of anti-tuberculosis drug induced adverse drug reactions (ADR) of retreatment pulmonary tuberculosis patients and the effect to therapy, and to encourage more attention be paid to the anti-tuberculosis drug induced ADR.Methods All 40 patients who conformed to the criteria of the research of retreatment pulmonary tuberculosis treatment of “Eleventh Five Year Plan” National Science and Technology major projects were enrolled from July, 2009 to December, 2011, the occurrence and results of ADR under close supervision through the whole course were analyzed.Results The ADR incidence rate of 40 retreatment pulmonary tuberculosis patients was 97.5% (39/40). Among those results, the highest incidence was hyperuricacidemia (85.00% (34/40)), others in sequences were the blood system damage (70.00% (28/40)) and liver function damage (40.00% (16/40)). The occurrence rates of ADR for once, twice, three times and four times were 2.50% (1/40), 40.00% (16/40), 30.00% (12/40) and 22.50% (9/40). The mild ADR incidence rate was 77.27% (85/110), the medium ADR incidence was 22.73% (25/110) and the severe ADR incidence rate was 0.00% (0/110). 50.91% (56/110) of ADR did not need special treatment, 36.36% (40/110) of ADR just needed symptomatic treatment and discontinuation was not required,11.82% (13/110) of ADR required discontinuation of anti-tuberculosis drug and needed symptomatic treatment, and only 0.91% (1/110) ADR patients could not tolerate the treatment of primary programs and dropped out.Conclusion The ADR incidence rate of retreatment pulmonary tuberculosis chemotherapy and occurrence frequency are higher, which decrease the patients’ compliance during treatment and bring difficulties to tuberculosis control. It must attract the clinical high attention to detect, diagnose, and manage ADR timely to ensure the patients complete treatment.