Abstract: Objective To analyze the clinical diagnosis and treatment of allergic skin rash caused by the antituberculosis drugs of fixed-dose combination (FDC), and to guide the clinical practice.Methods We analyzed retrospectively clinical data of allergic skin rash, including basic information, clinical manifestations, diagnosis and treatment, from 32 cases treated with antituberculosis drugs of FDC in organization for tuberculosis prevention during May 2005 to July 2015. The type of allergic drug and clinical features were summarized.Results This group of antituberculosis drug of FDC induced allergic rash was mainly measles-like (37.5%, 12/32) or urticaria-like (31.5%, 10/32). Time to allergy medication taken was from 2 weeks to 1 months, of which 1 to 3 weeks was common. The rate of allergic skin rash caused by FDC was ethambutol (37.5%, 12/32), pyrazinamide (21.87%, 7/32), isoniazid (12.50%, 4/32) and rifampicin (3.12%, 1/32). All patients with allergic skin rash were cure after stopping the medicine and clinical symptomatic treatment.Conclusion The main types of allergic skin rash caused by antituberculosis drugs of FDC are the measles-like and urticaria-like. Early determination of the type of allergic skin rash caused by FDC and treatment in time will get the better prognosis.