Abstract: Objective To understand the adverse reactions caused by first-line antituberculosis (anti-TB) drugs in new bacteriological positive pulmonary tuberculosis (PTB) patients.Methods Adverse reactions of 200 cases of new bacteriological positive PTB patients diagnosed and treated in Yuexiu TB Control Institute from September 2012 to April 2013 were analyzed. The cases were divided into adverse reactions group and no adverse reactions group, abnormal liver function group and normal liver function group. The differences between the two groups were analyzed.Results There were 127 cases with adverse reaction, and the incidence rate was 63.5% (127/200), abnormal liver function appeared in 50 cases, and the incidence rate was 25% (50/200). There were 111 cases with the adverse reaction appeared in 2 months of the treatment. Positive rate of hepatitis B surface antigen in abnormal liver function group was 18.0% (9/50), and that in normal liver function group was 8.0% (12/150), and the difference was statistically significant (χ²＝3.99, P=0.046). 173 cases were cured, and the cure rate was 86.5% (173/200).Conclusion The incidence rate of adverse reaction caused by anti-TB drugs is higher, while the impact on treatment regimen and treatment effect is small.