Abstract: Objective We analyzed the adverse drug reactions in patients with tuberculosis for providing re-ferences to prevent and deal with the adverse drug reactions in high-risk patients.Methods We retrospectively analyzed 8492 patients with tuberculosis of Third people’s Hospital of Shenzhen from January 2011 to December 2014. All data were from the in-patient medical record room and the out-patient electronic medical record database. According to the annual review of tuberculosis treatment in 2014, 8492 patients were divided into general group (6689 cases) and high-risk group (1803 cases). The high-risk group was divided into three subgroups with diabetes (732 cases), AIDS (267 cases) and CHB (697 cases) differently. The major adverse reactions of anti-tuberculosis drugs in all groups were recorded. And the data were entered into the SPSS 19.0 software suite and analyzed using Chi-square test.Results The overall adverse drug reaction rate was 13.9% (929/6689) in general patients and 26.4% (476/1803) in high-risk patients. The difference between the two groups was statistically significant (χ²=33.785, P<0.0001). The severe adverse drug reaction rate was 1.1% (73/6689) in general patients and 6.4% (116/1803) in high-risk patients. There was no statistically significant difference between the two groups (χ²=6.012,P=0.198). In high-risk subgroup, the adverse drug reaction rate was 24.7% (181/732) in patients with diabetes mellitus; 36.3% (97/267) in patients with AIDS and 28.4% (198/697) in patients with chronic hepatitis B. There was no statistically significant difference between the subgroups (χ²=17.30,P=0.068).Conclusion Adverse drug reactions are more common seen in high-risk patients than in general patients, we should pay more attention to the prevention and treatment of high-risk patients.