Abstract: Objective To analyze the clinical features of drug-resistant tuberculosis, and to understand mycobacteria, patient’s conditions and outcomes of treatment in drug-resistant TB patients.Methods The clinical data of 110 drug-resistant TB cases, at Shenzhen Chronic Disease Control and Prevention Centre from January 2009 to December 2012, were collected. Patients were assayed with smear, culture, X-Ray, bacterial identification and drug sensitivity test, etc. Effects and side effects were observed during treatment. A comprehensive assessment was conducted by experts through discussion.Results The prominent symptoms of 110 cases of drug-resistant TB were cough and expectoration. Amongst all patients, 21.8% (24/110) demonstrated Multi-drug resistant tuberculosis, and 19.1% (21/110) contracted tuberculosis resistant to 3 and more drugs. 57.3% (63/110) of patients had bila-teral lung field affected. The rate of +++ and above among the patients with sputum smear + was 30.9% (34/110). The rate of lesions absorption was 80.9% (89/110).The rate of successful treatment was 76.4% (84/110), while that of failure amounted to 13.6% (15/110).Conclusion The drug-resistant tuberculosis possesses apparent respiratory manifestation,It was shown there had been a high percentage of multi-drug resistant TB and poly-resistant TB, damaging the lung severely. We should enhance drug-resistant tuberculosis control and reduce the propagation of drug-resistant TB.