Abstract: Objective To understand the effect for The Global Fund TB Project (GFTP) in patients detection and treatment management of the floating population in Heifei city, Anhui province, China.Methods Use the quarterly statement of the GFTP and Tuberculosis Information Systems (TBIS),to analyze the patients detection, treatment outcome and cross-regional management between 275 floating population tuberculosis patients (originated from quarterly statement) and 5 019 461 registered population (the 2010 census data) among July 2010 to June 2012, then using χ² test to compare the differences about household registered patients, and to explore the reasons for P<0.05 was considered statistically significant.Results Two hundred and severty five floating population tuberculosis patients were found during the program in two years, the registered rate is 40.26/100 000 (275/683 005). Among it, the registered rate of new sputum smear positive is 17.42/100 000 (119/683 005), the registered rate of new sputum smear negative is 21.52/100 000 (147/683 005), the registered rate of resident tuberculosis patients is 151.77/100 000 (7618/5 019 461), the difference was statistically significant (χ²=540.8, P<0.01). Patient population flows mainly from suburban 38.46% (106/275) and the province 34.07% (94/275) in Hefei. Patient management across the region shows that the floating population of patients transferred out rate 23.64% (65/275), turn rate 8.73% (24/275), turn the place into the patient rates were 89.23% (58/65) and 95.83% (23/24),the diffe-rence was not statistically significant (χ²=0.3013, P>0.05).Treatment and outcome of floating population patients with pulmonary tuberculosis, for locally and overseas to achieve successful treatment rates were 91.71% (199/217) and 58.62% (34/58), the difference was statistically significant (χ²=38.713,P<0.01).Conclusion GFTP has achieved good results in Hefei, the feature of patients among floating population was grasped preliminary,the finding level and successful treatment rate was improved, and insist to the floating population in the discovery is necessary to complete the treatment.