Abstract: Objective To improve the cure rate of multidrug-resistant pulmonary tuberculosis (MDR-TB) patients. Methods The clinical data of 93 MDR-TB patients registered and treated from Mar 2009 to May 2013 were analyzed, and the data were based on Global Fund Project of Ulanqab City in Inner Mongolia. Results The patients’ conditions were alleviated significantly due to the MDR-TB treatment. The total effective rate of cough and expectoration was 84.51% (60/71), and for chest pain and chest oppression was 85.00% (17/20), the total effective rate of fatigue and night sweats was 62.79% (27/43), and that for fever was 94.74% (18/19), the total effective rate of chest X-ray and CT was 77.42% (72/93). Twenty cases were cured (31.25%, 20/64), 9 cases were failed (14.06%, 9/64), 10 cases were died (15.62%, 10/64), and 19 cases were defaulted (29.69%, 19/64), the other 6 cases(2 cases to the field of treatment, 4 patients did not complete the course withdrawal, sputum knot line to cure) account for 9.38%(6/64). Conclusion Multidrug-resistant tuberculosis patients after treatment, the clini-cal symptoms and signs were obviously improved, but the cure rate of success is still not ideal, should cause enough attention.