结核病与肺部健康杂志 ›› 2015, Vol. 4 ›› Issue (1): 32-35.doi: 10.3969/j.issn.2095-3755.2015.01.007

• 论著 • 上一篇    下一篇

密切接触者PPD强阳性率在学校结核病暴发风险评估中的应用价值

陈麒,齐怡,周颖,周令,路希维   

  1. 116044 大连医科大学公共卫生学院(陈麒、周令);大连市结核病医院(齐怡、周颖、路希维)
  • 收稿日期:2014-11-17 出版日期:2015-03-14 发布日期:2015-03-14
  • 通信作者: 路希维,Email:yiluxiwei@126.com

The value of PPD positive rate of close contacts in the tuberculosis outbreak risk assessment in school

CHEN Qi*, QI Yi, ZHOU Ying, ZHOU Ling, LU Xi-wei   

  1. *School of Public Health, Dalian Medical University, Dalian 116044, China
  • Received:2014-11-17 Online:2015-03-14 Published:2015-03-14
  • Contact: LU Xi-wei, Email:yiluxiwei@126.com

摘要: 目的 对大连市登记的散发学生肺结核患者密切接触者进行回顾性分析,探究PPD强阳性率在学校结核病暴发风险评估中的应用价值。方法 对2010年12月至2013年12月间录入全国结核病管理信息系统中的大连市散发学生肺结核患者及其密切接触者资料进行收集和分析,共纳入散发肺结核患者228例,并对其9863名密切接触者随访12个月。观察涂阳和涂阴患者的密切接触者发病情况与PPD强阳性率(PPD硬结平均直径≥15 mm)分布,采用ROC曲线获取结核病暴发和续发患者的PPD强阳性率的截断值。结果 228例散发肺结核患者中,涂阳肺结核39例,其密切接触者发生“偶然聚集”和“结核病暴发”的发生率分别为17.9% (7/39)和10.3% (4/39);涂阴肺结核189例,其密切接触者发生“偶然聚集”和“结核病暴发”的发生率均为7.9% (15/189);两者比较,χ2=0.60、0.23,P值均>0.05。涂阳患者密切接触者的强阳性率均值为(16.0±0.8)%;涂阴肺结核患者密切接触者的强阳性率均值为(15.3±0.9)%,两组间差异无统计学意义,χ2=2.41,P>0.05。大连市入学新生的PPD强阳性率为(6.5±0.5)%,与发生结核病疫情的不同级别(无聚集、偶然聚集和聚集性暴发)的PPD强阳性率均值的组间差异有统计学意义,χ2=26.14,P<0.01。将随访期12个月内发生续发患者作为诊断标准,绘制PPD强阳性率ROC曲线,特异度为85.0%,敏感度为70.0%,曲线下面积为0.78,截断值为25.5%。将结核病暴发作为诊断标准,绘制PPD强阳性率ROC曲线,特异度和敏感度均为78.0%,曲线下面积为0.81,截断值为21.5%。结论 涂阳和涂阴患者具有相同的引发结核病暴发事件的风险。高暴露群体PPD强阳性率超过21.5%是产生续发患者的预警指标,提示密切接触者具有发病可能,应及时进行干预。

Abstract: Objective To explore the value of PPD positive rate in school tuberculosis outbreaks risk assessment by using retrospective analysis of close contacts of sporadic cases of tuberculosis registered in the Dalian city. Methods We collected and analyzed the sporadic student TB cases (228 cases in total) registered in the National TB management information system between December 2010 and December 2013, and followed up their 9863 close contacts for one-year. We observed the TB incidence and PPD strong positive (PPD average diameter ≥15 mm)distribution of these contacts, and used ROC curves to get cut-off value of PPD strong positive rate of TB outbreaks and occurrence of new cases among contacts. Results In 228 sporadic cases, 39 cases were smear-positive pulmonary tuberculosis, and the incidence of accidental occurrence aggregation and tuberculosis outbreaks were 7/39(17.9%) and 4/39(10.3%) respectively among close contacts; in 189 smear-negative TB cases, both incidence of accidental occurrence aggregation and tuberculosis outbreaks were 15/189(7.9%), with no statistical significance, all P>0.05 (χ2=0.60, 0.23). PPD positive rate of close contacts of smear-positive TB cases is (16.0±0.8)%; comparing with close contacts of smear-negative TB cases of (15.3±0.9)%, with no statistical significance (χ2=2.41, P>0.05). PPD strong positive average rate of freshmen in Dalian was (6.5±0.5)%, the average PPD strong positive rates varied with TB epidemic levels, χ2=26.14, P<0.01. Using the continuous cases occurred in one year as a criterion to draw PPD strong positive rate ROC curve, specificity is 85.0%,sensitivity is 70.0%,AUC=0.78, the predictive cut-off value is 25.5%. When use occurrence of TB outbreaks as criterion to draw ROC, AUC=0.81, both specificity and sensitivity were 0.78,cut-off value is 21.5%. Conclusion Both smear-positive and smear-negative patients have the same risk of causing tuberculosis outbreaks. Over 21.5% of PPD strong positive rate is the warning indicator of continuous cases occurrence, it also suggests that close contacts have the possibility of TB incident and intervention should be given in a timely manner.