程序性细胞死亡及其在慢性阻塞性肺疾病中的研究进展

doi:10.19983/j.issn.2096-8493.20230092

摘要/Abstract

摘要：

慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD,简称“慢阻肺”)引发了沉重的社会经济负担,其发病的潜在细胞和分子生物学机制尚未完全阐明。研究细胞死亡的调控对慢阻肺不同表型的机制研究至关重要。程序性细胞死亡(programmed cell death,PCD)是由细胞内特定基因调控的分子程序介导的细胞死亡过程,涉及效应分子参与的信号级联反应,具有独特的生化特征、形态特征和免疫学后果,在维持细胞稳态等方面发挥重要作用。常见的PCD模式有细胞凋亡、自噬、坏死性凋亡和焦亡,以及近年发现的铁死亡。多种PCD模式之间存在交叉互作,共同影响细胞的结局。越来越多的研究表明,PCD与慢阻肺的发生发展密切相关。深入了解不同PCD模式与慢阻肺发病的关系并进一步探讨各种PCD模式间的相互作用,有利于实现慢阻肺的多靶点综合干预,为慢阻肺患者的防治提供新的选择。

关键词: 免疫球蛋白类, 肺疾病,慢性阻塞性, 总结性报告(主题)

Abstract:

Chronic obstructive pulmonary disease (COPD) has caused a considerable economic and social burden. However, its underlying cellular and molecular biological mechanisms have not been fully understood. Studying the regulation of cell death is crucial for exploring the mechanisms of different phenotypes in COPD. Programmed cell death (PCD) is a process of cell death mediated by molecular programs regulated by specific genes, involving signaling cascades. It has unique biochemical, morphological, and immunological characteristics and plays an important role in maintaining cellular homeostasis. The common PCD patterns include cell apoptosis, autophagy, necrotic apoptosis, and pyroptosis, as well as ferroptosis discovered in recent years. There is a cross interaction between multiple PCD modes, which together affect the cell outcome. More and more studies have shown that PCD is closely related to the occurrence and development of COPD. Deeply understanding the relationship between different PCD modes and the pathogenesis of COPD and further exploring the interactions between various PCD modes are beneficial for achieving comprehensive intervention in COPD, which may provide new choices for the prevention and treatment of patients with COPD.

Key words: Immunoglobulins, Pulmonary disease, chronic obstructive, Consensus development conferences as topic

中图分类号:

崔亚楠, 陈燕. 程序性细胞死亡及其在慢性阻塞性肺疾病中的研究进展[J]. 结核与肺部疾病杂志, 2023, 4(5): 397-406. doi: 10.19983/j.issn.2096-8493.20230092

Cui Yanan, Chen Yan. Programmed cell death and its research progress in chronic obstructive pulmonary disease[J]. Journal of Tuberculosis and Lung Disease, 2023, 4(5): 397-406. doi: 10.19983/j.issn.2096-8493.20230092

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