多种炎症因子在非小细胞肺癌中的作用与临床价值

doi:10.19983/j.issn.2096-8493.20260089

结核与肺部疾病杂志 2026, Vol. 7 Issue (5): 700-707 DOI: 10.19983/j.issn.2096-8493.20260089

多种炎症因子在非小细胞肺癌中的作用与临床价值

李晶晶¹, 陆霓虹²(), 杨艳³

¹ 大理大学公共卫生学院, 大理 671003
² 昆明医科大学第二附属医院呼吸与危重症医学科, 昆明 650000
³ 云南省昆明市第三人民医院呼吸与危重症医学科, 昆明 650041

收稿日期:2026-04-27 出版日期:2026-10-20 发布日期:2026-10-19
通信作者: 陆霓虹 E-mail:602157606@qq.com
基金资助:
云南省科技厅科技计划项目(202303AC100026);云南省教育厅科学研究基金项目(2025J0798);国家自然科学基金地区科学基金项目(82460016);云南省级临床医学中心科研项目(2024YNLCYXZ0209)

The role and clinical value of inflammation factors in non-small cell lung cancer

Li Jingjing¹, Lu Nihong²(), Yang Yan³

¹ Public Health College of Dali University, 671003 Dali, China
² Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital of Kunming Medical University, Kunming 650000, China
³ Department of Respiratory and Critical Care Medicine of the Third People’s Hospital of Kunming, Kunming 650041, China

Received:2026-04-27 Online:2026-10-20 Published:2026-10-19
Contact: Lu Nihong E-mail:602157606@qq.com
Supported by:
Science and Technology Plan Project of Yunnan Provincial Department of Science and Technology(202303AC100026);Scientific Research Fund Project of Yunnan Provincial Department of Education(2025J0798);National Natural Science Foundation of China Regional Science Foundation Project(82460016);Yunnan Provincial Clinical Medicine Center Research Project(2024YNLCYXZ0209)

摘要/Abstract

摘要：

非小细胞肺癌(non-small cell lung cancer, NSCLC)在肺癌中的占比高达80%以上,是全球致死率最高的肿瘤。在肿瘤微环境中,炎症因子表达失衡是驱动免疫抑制与治疗抵抗的核心环节,失衡的炎症因子网络会导致肿瘤进一步发生发展。综合目前炎症因子与肿瘤进展的前沿论点,笔者系统梳理了9种细胞因子在NSCLC中的生物学功能及调控机制,按照功能特征分类,根据不同类型因子的不同作用,阐释及总结了白细胞介素-1β、白细胞介素-6、白细胞介素-8、白细胞介素-10、白细胞介素-12p70、白细胞介素-17、肿瘤坏死因子-α、α干扰素、γ干扰素这9种炎症因子的作用机制。通过深入解析这些细胞因子的条件性调控规律,不仅有助于筛选预测免疫检查点抑制剂应答与不良反应的候选标志物,也为开发靶向特定信号轴的新型联合策略奠定理论基础。

关键词: 癌,非小细胞肺, 炎症趋化因子类, 细胞因子类, 白细胞介素类

Abstract:

Non-small cell lung cancer (NSCLC) accounts for more than 80% of all lung cancer cases and ranks as the leading cause of cancer-related death worldwide. In the tumor microenvironment, dysregulated expression of inflammatory cytokines serves as a core driver of immunosuppression and therapeutic resistance, and such dysregulated cytokine networks further facilitate tumor initiation and progression. Based on the latest research advances on inflammatory cytokines and tumor progression, this review systematically summarizes the biological functions and regulatory mechanisms of nine key cytokines involved in NSCLC. Classified by their functional characteristics and biological roles, this review further elaborates the action mechanisms of interleukin-1β, interleukin-6, interleukin-8, interleukin-10, interleukin-12p70, interleukin-17, tumor necrosis factor-α, interferon-α and interferon-γ. In-depth analysis of the context-dependent regulatory patterns of these cytokines not only facilitates the identification of candidate biomarkers for predicting response and adverse events to immune checkpoint inhibitors, but also lays a theoretical foundation for the development of novel combination strategies targeting specific signaling axes.

Key words: Carcinoma, non-small-cell lung, Chemokines, Cytokines, Interleukins

中图分类号:

R734

李晶晶, 陆霓虹, 杨艳. 多种炎症因子在非小细胞肺癌中的作用与临床价值[J]. 结核与肺部疾病杂志,2026, 7(5): 700-707. doi: 10.19983/j.issn.2096-8493.20260089

Li Jingjing, Lu Nihong, Yang Yan. The role and clinical value of inflammation factors in non-small cell lung cancer[J]. Journal of Tuberculosis and Lung Disease, 2026, 7(5): 700-707. doi: 10.19983/j.issn.2096-8493.20260089

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多种炎症因子在非小细胞肺癌中的作用与临床价值

The role and clinical value of inflammation factors in non-small cell lung cancer

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