结核病与肺部健康杂志 ›› 2018, Vol. 7 ›› Issue (1): 64-67.doi: 10.3969/j.issn.2095-3755.2018.01.014

• 论著 • 上一篇    下一篇

常规治疗加复合乳酸菌口服对中老年慢性阻塞性肺疾病急性加重期的疗效

李树贵()   

  1. 114000 鞍山市第三医院重症监护病房
  • 收稿日期:2018-01-15 出版日期:2018-03-30 发布日期:2018-07-24
  • 通信作者: 李树贵 E-mail:aslishugui@163.com

Effects of conventional therapy combined with oral lactobacillus for elderly patients with acute exacerbation of chronic obstructive pulmonary disease

Shu-gui LI()   

  1. Intensive Care Unit, Third Hospital of Anshan City, Anshan 114000, China
  • Received:2018-01-15 Online:2018-03-30 Published:2018-07-24
  • Contact: Shu-gui LI E-mail:aslishugui@163.com

摘要:

目的 探究复合乳酸菌治疗中老年慢性阻塞性肺疾病急性加重期(AECOPD)的疗效。方法 选自鞍山市第三医院2015年5月至2017年8月收治的120例AECOPD患者,采用随机数字表法分为对照组(60例)和观察组(60例)。对照组予以常规治疗,观察组在对照组常规治疗的基础上增加复合乳酸菌治疗,比较两组患者的肺功能指标[第1秒用力呼气量(FEV1)、用力肺活量(FVC)、第1秒用力呼气量占用力肺活量的百分比(FEV1/FVC)]、功能性呼吸困难分级评分、血常规指标、不良反应发生率、病死率、氧合指数及住院时间。结果 观察组患者不良反应发生率为3.33%(2/60),与对照组的6.67%(4/60)相比,差异无统计学意义(χ 2=0.70,P=0.402);观察组患者病死率为1.67%(1/60),与对照组的3.33%(2/60)相比,差异无统计学意义(χ 2=0.34,P=0.559);观察组患者FEV1为(1.89±0.53)L,高于对照组的(1.61±0.43)L,差异有统计学意义(t=2.91,P=0.004);观察组FVC(1.79±0.31)L,高于对照组FVC(1.37±0.16)L,差异有统计学意义(t=8.83,P=0.000);观察组FEV1/FVC为(64.01±5.18)%,高于对照组的(55.89±6.41)%(t=6.76,P=0.000),差异有统计学意义;功能性呼吸困难分级评分观察组得分为(2.31±1.35)分,低于对照组的(2.97±1.28)分,差异有统计学意义(t=2.41,P=0.018);血常规检查,观察组白细胞计数为(7.49±1.98)×10 9/L,低于对照组的(9.01±2.72)×10 9/L,差异有统计学意义(t=3.08,P=0.003);观察组中性粒细胞百分比为(65.87±7.65)%,低于对照组的(74.16±11.60)%,差异有统计学意义(t=4.04,P=0.000);氧合指数检测,观察组氧合指数为(351.01±65.79),高于对照组(304.02±82.11),差异有统计学意义(t=3.06,P=0.003);观察组住院时间为(7.25±2.31)d,低于对照组(9.94±3.52)d,差异有统计学意义(t=4.32,P=0.000)。 结论 复合乳酸菌治疗中老年AECOPD的疗效显著,可有效修复肺功能损害。

关键词: 肺疾病, 慢性阻塞性, 发作, 急性肺损伤, 有益菌种, 疗效比较研究, 复合乳酸菌

Abstract:

Objective To explore the effects of conventional therapy combined with oral lactobacillus for elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods A total of 120 cases of AECOPD patients in third hospitals of Anshan city from May 2015 to August 2017were divided into the observation group (n=60) and the control group (n=60) using digital table method. The control group was treated with conventional therapy,and the observation group was combined with lactobacillus. Pulmonary function index (forced expiratory volume in one second (FEV1), forced vital capacity (FVC), forced expiratory volume in one second as percentage of predicted value (FEV1/FVC)), unctional dyspnea grade score, blood routine, incidence of adverse reactions, fatality rate, oxygenation index and time of hospitalization were compared between the two groups.Results The incidence of adverse reactions in the observation group was 3.33% (2/60) and was 6.67% (4/60) in the control group, the difference was not statistically significant (χ 2=0.70, P=0.402). The fatality rates in the observation and control groups were 1.67% (1/60) and 3.33% (2/60) (χ 2=0.34, P=0.559); the FEV1 of the two groups were (1.89±0.53)L vs. (1.61±0.43)L (t=2.91,P=0.004); the FVC of were (1.79±0.31)L vs. (1.61±0.43)L (t=8.83, P=0.000); the FEV1/FVC were (64.01±5.18)% vs. (55.89±6.41)% (t=6.76, P=0.000); the unctional dyspnea grade scores were (2.31±1.35) vs. (2.97±1.28) (t=2.41, P=0.018); as to blood routine examination, WBC counts were (7.49±1.98)×10 9/L vs. (9.01±2.72)×10 9/L (t=3.08, P=0.003), neutrophilic granulocytes were (65.87±7.65)% vs. (74.16±11.60)% (t=4.04, P=0.000); Oxygenation indexes were (351.01±65.79) vs. (304.02±82.11) (t=3.06,P=0.003); times of hospitalization were (7.25±2.31)d vs. (9.94±3.52)d; all the above differences were statistically significant (t=4.32,P=0.000). Conclusion The efficacy of Lactobacillus for elderly patients with AECOPD was significant. It helps to restore lung function.

Key words: Pulmonary disease, Chronic obstructive, Seizures, Acute lung injury, Probiotics, Comparative effectiveness research, Lactobacillus