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Journal of Tuberculosis and Lung Disease ›› 2024, Vol. 5 ›› Issue (1): 70-80.doi: 10.19983/j.issn.2096-8493.20230112

• Review Articles • Previous Articles     Next Articles

Research progress of comprehensive treatment for tuberculosis

Liang Chen1, Tang Shenjie2(), Lin Minggui1()   

  1. 1Department of Infection,Beijing Tsinghua Changgeng Hospital,Tsinghua University, Beijing 102218, China
    2Clinical Medical Center of Tuberculosis, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute/Tuberculosis Prevention and Control Clinical Center Office of Chinese Center for Disease Control and Prevention, Beijing 101149, China
  • Received:2023-09-13 Online:2024-02-20 Published:2024-02-02
  • Contact: Lin Minggui,Email:linminggui309301@126.com;Tang Shenjie, Email: tangsj1106@vip.sina.com
  • Supported by:
    National Science and Technology Major Project for “Prevention and Treatment of AIDS,Virus Hepatitis and Other Serious Infectious Diseases”(2020ZX10001008)

Abstract:

Tuberculosis is a chronic infectious disease caused by the infection of Mycobacterium tuberculosis complex. Although the success of BCG vaccine and effective anti-tuberculosis drugs has provided effective means of tuberculosis prevention and treatment, it is still quite challenging to cure tuberculosis completely with the continuous flow of population, and continuous emergence of HIV infection, usage of immunosuppressive drugs for special diseases and drug-resistant tuberculosis, especially for that the prevalence of COVID-19 since the end of 2019 has set back the epidemic control of tuberculosis for at least 5-8 years. Curing tuberculosis patients thoroughly is still the key measure to cut off the transmission of Mycobacterium tuberculosis and eliminate disease transmission. On the basis of anti-tuberculosis chemotherapy, combined with comprehensive treatment methods such as surgical treatment, interventional therapy, immunotherapy, nutritional therapy, traditional Chinese medicine treatment, psychological therapy, and rehabilitation therapy, it is beneficial to improve the patient’s cure rate and reduce adverse reactions. Clinicians need to comprehensively evaluate the specific condition of patients and choose individualized comprehensive treatment plans in a targeted manner to achieve the optimal treatment effect. This article reviews the research progress of tuberculosis comprehensive treatment in recent years.

Key words: Tuberculosis, Mycobacterium tuberculosis, Drug resistance,multiple, Antitubercular agents

CLC Number: