Abstract:

Objective: To analyze the infection situation and influencing factors of latent tuberculosis infection (LTBI) among high school sophomores. Methods: Sophomore high school students with no previous history of tuberculosis in schools of Hechuan District, Chongqing in 2022 were selected to take purified protein derivative of tuberculin (PPD) test to understand the LTBI situation among them. A simple random sampling was conducted to select LTBI students and students with negative PPD test results to receive a questionnaire survey, including questions about demographic characteristics, contact history and knowledge of tuberculosis, etc. One thousand pieces of questionnaire were distributed and 993 valid questionnaire were collected, with an effective rate of 99.3%.Univariable and multivariable logistic regression were done to analyze the influencing factors of LTBI in sophomore students. Results: Among 8873 high school sophomores,there were 1521 cases of LTBI,with an infection rate of 17.14%. Multivariable logistic analysis showed that the risk factors of LTBI among high school sophomores were female students (OR=1.451, 95%CI: 1.025-2.055), students having a history of close contact with tuberculosis patients (OR=8.523, 95%CI: 3.609-20.127), while students’ mother having college or above education level (OR=0.401, 95%CI: 0.235-0.683), participation in physical exercise (OR=0.579, 95%CI: 0.387-0.866), having good knowledge of core message of tuberculosis prevention and control(OR=0.079, 95%CI: 0.054-0.115) were protective factors. Conclusion: The LTBI rate among sophomore high school students in Hechuan District, Chongqing is relatively high. LTBI acquisition are affected by gender, history of close contact with tuberculosis patients, mother’s education level, physical exercise, and awareness of core tuberculosis message. Targeted health education and preventive medication can be carried out.

Key words: Students, Tuberculosis,pulmonary, Tuberculin, Factor analysis,statistical