Analysis of risk factors of anti-tuberculosis drug-induced liver injury in 7043 tuberculosis patients in Guiyang

doi:10.3969/j.issn.2096-8493.20210094

Abstract

Abstract:

Objective To analyze the risk factors of anti-tuberculosis drug-induced liver injury (ATB-DILI). Methods The clinical data of 7043 tuberculosis (TB) patients admitted to Guiyang Public Health Treatment Center from January 2014 to December 2016 were retrospectively collected,all the patients were followed up. Logistic regression method was used to analyze the risk factors related to age, gender, drinking history, nutritional status and complicated underlying liver disease. Results Among the 7043 tuberculosis patients, ATB-DILI were found in 319 cases (4.53%) (male: 179 (56.11%), female: 140 (43.89%)).Logistic regression analysis showed that aged ≥60 years (OR (95%CI)=0.629 (0.458-0.862), P=0.004) was protective factor for ATB-DILI; female (OR (95%CI)=1.394 (1.092-1.780), P=0.008), current alcohol consumption (OR (95%CI)=2.222 (1.569-3.148), P<0.001), malnutrition (OR (95%CI)=2.051 (1.589-2.648), P<0.001) and complicated with underlying liver disease (OR (95%CI)=1.892 (1.158-3.092), P=0.011) were risk factors for ATB-DILI. Conclusion For tuberculosis patients, female, <60 years old, current alcohol consumption, malnutrition and complicated with underlying liver disease were high-risk groups for ATB-DILI during treatment, and individualized anti-tuberculosis programs should be implemented for these patients.

Key words: Tuberculosis, Antitubercular agents, Drug-induced liver injury, Risk factors

CHEN Jing, ZHAO Peng. Analysis of risk factors of anti-tuberculosis drug-induced liver injury in 7043 tuberculosis patients in Guiyang[J]. Journal of Tuberculosis and Lung Disease , 2021, 2(4): 335-339. doi: 10.3969/j.issn.2096-8493.20210094

Figures/Tables 3

References 28

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因素	非ATB-DILI组(6724例)	ATB-DILI组(319例)	χ²值	P值
年龄组(岁)			4.581	0.032
<60	5361(79.73)	270(84.63)
≥60	1363(20.27)	49(15.37)
性别			2.568	0.109
男性	4075(60.60)	179(56.11)
女性	2649(39.40)	140(43.89)
饮酒史			24.429	<0.001
从不饮酒	5983(88.98)	268(84.01)
曾经饮酒	209(3.11)	3(0.94)
现在饮酒	532(7.91)	48(15.05)
因素	非ATB-DILI组(6724例)	ATB-DILI组(319例)	χ²值	P值
营养不良			32.423	<0.001
无	5611(83.45)	227(71.16)
有	1113(16.55)	92(28.84)
并发基础肝病			8.859	0.003
无	6523(97.01)	300(94.04)
有	201(2.99)	19(5.96)
使用护肝药物			1.659	0.198
否	3272(48.66)	167(52.35)
是	3452(51.34)	152(47.65)

因素	赋值
年龄	0=<60岁;1=≥60岁
性别	0=男;1=女
饮酒史	0=从不饮酒;1=曾经饮酒;2=目前饮酒
营养不良	0=否;1=有
并发基础肝病	0=否;1=有

因素	β值	$s_{\bar{x}}$值	Wald χ²值	P值	OR(95%CI)值
女性	0.332	0.125	7.090	0.008	1.394(1.092~1.780)
≥60岁	-0.464	0.161	8.280	0.004	0.629(0.458~0.862)
现在饮酒	0.799	0.178	20.212	<0.001	2.222(1.569~3.148)
营养不良	0.719	0.130	30.394	<0.001	2.051(1.589~2.648)
并发基础肝病	0.638	0.250	6.484	0.011	1.892(1.158~3.092)