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Journal of Tuberculosis and Lung Disease ›› 2021, Vol. 2 ›› Issue (3): 273-276.doi: 10.3969/j.issn.2096-8493.20210035

• Review Articles • Previous Articles     Next Articles

Research progress on the application of biomarkers in differential diagnosis of benign and malignant pulmonary nodules

CUI Kai, ZHANG Xiao-ju()   

  1. Department of Respiratory Medicine, People’s Hospital of Zhengzhou University, Zhengzhou 450003, China
  • Received:2021-05-11 Online:2021-09-30 Published:2021-09-24
  • Contact: ZHANG Xiao-ju E-mail:15837101166@163.com

Abstract:

Biomarker detection is a simple and convenient method for monitoring and follow-up, which is widely used in the qualitative diagnosis of pulmonary nodules and the study of malignant evolution. Different biomarkers have different specificity and sensitivity in the diagnosis of malignant pulmonary nodules. The combined detection of multiple biomarkers or the evaluation combined with low-dose spiral CT can significantly improve the diagnostic efficiency of malignant pulmonary nodules. The clinical value and research progress of biomarkers in the differential diagnosis of benign and malignant pulmonary nodules were reviewed to provide reasonable suggestions for clinical diagnosis and treatment, and hierarchical management of patients with pulmonary nodules.

Key words: Lung neoplasms, Biomarkers, Diagnosis, differential