Abstract:

Objective To explore the effects of conventional therapy combined with oral lactobacillus for elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods A total of 120 cases of AECOPD patients in third hospitals of Anshan city from May 2015 to August 2017were divided into the observation group (n=60) and the control group (n=60) using digital table method. The control group was treated with conventional therapy,and the observation group was combined with lactobacillus. Pulmonary function index (forced expiratory volume in one second (FEV₁), forced vital capacity (FVC), forced expiratory volume in one second as percentage of predicted value (FEV₁/FVC)), unctional dyspnea grade score, blood routine, incidence of adverse reactions, fatality rate, oxygenation index and time of hospitalization were compared between the two groups.Results The incidence of adverse reactions in the observation group was 3.33% (2/60) and was 6.67% (4/60) in the control group, the difference was not statistically significant (χ ²=0.70, P=0.402). The fatality rates in the observation and control groups were 1.67% (1/60) and 3.33% (2/60) (χ ²=0.34, P=0.559); the FEV₁ of the two groups were (1.89±0.53)L vs. (1.61±0.43)L (t=2.91,P=0.004); the FVC of were (1.79±0.31)L vs. (1.61±0.43)L (t=8.83, P=0.000); the FEV₁/FVC were (64.01±5.18)% vs. (55.89±6.41)% (t=6.76, P=0.000); the unctional dyspnea grade scores were (2.31±1.35) vs. (2.97±1.28) (t=2.41, P=0.018); as to blood routine examination, WBC counts were (7.49±1.98)×10 ⁹/L vs. (9.01±2.72)×10 ⁹/L (t=3.08, P=0.003), neutrophilic granulocytes were (65.87±7.65)% vs. (74.16±11.60)% (t=4.04, P=0.000); Oxygenation indexes were (351.01±65.79) vs. (304.02±82.11) (t=3.06,P=0.003); times of hospitalization were (7.25±2.31)d vs. (9.94±3.52)d; all the above differences were statistically significant (t=4.32,P=0.000). Conclusion The efficacy of Lactobacillus for elderly patients with AECOPD was significant. It helps to restore lung function.

Key words: Pulmonary disease, Chronic obstructive, Seizures, Acute lung injury, Probiotics, Comparative effectiveness research, Lactobacillus