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Journal of Tuberculosis and Lung Disease ›› 2024, Vol. 5 ›› Issue (2): 113-119.doi: 10.19983/j.issn.2096-8493.2024016

• Original Articles • Previous Articles     Next Articles

Metagenomic next-generation sequencing assisted in the diagnosis of psittacosis: a case report and literature review

Yuan Yonglong1,2, Li Huimei3, Ma Dedong1()   

  1. 1Pulmonary and Critical Care Medicine, Qilu Hospital of Shandong University, Ji’nan 250012, China
    2Pulmonary and Critical Care Medicine, Zaozhuang Xuecheng People’s Hospital, Zaozhuang 277000, China
    3Pulmonary and Critical Care Medicine, Shandong Provincial Qianfoshan Hospital, Ji’nan 250012, China
  • Received:2023-12-14 Online:2024-04-20 Published:2024-04-11
  • Contact: Ma Dedong


Objective: To investigate the clinical features, epidemiological features, diagnosis, treatment and prognosis of psittacosis. Methods: A case of Chlamydia psittaci pneumonia admitted to the Pulmonary and Critical Care Medicine of Shandong Provincial Qianfoshan Hospital was retrospectively reviewed. The diagnosis and treatment was analyzed. Using “Psittacosis” as search terms, relevant literature was searched from the PubMed, Wanfang, WIP, CNKI databases and then analyzed. Results: The patient was 52-year-old, male, had a history of hypertension, and admitted to the hospital due to “fever and cough for 20 days”. He had been treated with moxifloxacin and cefoperazone-sulbactam before admission, but the condition did not improve. Psittacosis pneumonia was confirmed by detecting Chlamydia psittaci in the bronchoalveolar lavage fluid using metagenomic next-generation sequencing after that the patient was transferred to our department. The patient improved after treatment with levofloxacin combined with minocycline and was discharged from the hospital. Through literature review, it was found that psittacosis is a zoonotic disease that can affect multiple systems in the body, with the respiratory system being affected most commonly. This disease can be transmitted between humans. Metagenomic high-throughput sequencing technology has more advantages than traditional detection methods such as serology, pathogen isolation and culture, and polymerase chain reaction. Tetracycline drugs are the preferred treatment with a duration of 2-3 weeks. The prognosis of this disease is generally good, with an overall mortality rate of approximately 1%. Conclusion: Psittacosis is a zoonotic disease that requires early treatment. Because of lack of specificity of the clinical characteristics and examination results, the rates of misdiagnosis and missed diagnosis are high. Metagenomic high-throughput sequencing technology has advantages in diagnosing this disease. Tetracycline drugs are the preferred treatment with good prognosis in general.

Key words: Psittacosis, Chlamydophila pneumoniae, Metagenomic next-generation sequencing, Consensus development conferences as topic

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