Abstract:

Objective: To understand the epidemiological characteristics and treatment outcomes of etiological negative pulmonary tuberculosis (TB) patients in Tongzhou District of Beijing, so as to provide reference for formulating prevention and control strategies. Methods: The data of pulmonary TB (excluding drug-resistant pulmonary TB) patients registered in Tongzhou District from 2016 to 2020 was collected from the Chinese TB Management Information System.The medical record data of etiological negative patients was extracted according to periodic statistics tables generated by the system. Descriptive statistics was used to analyze the data. Results: From 2016 to 2020, a total of 3136 cases of pulmonary TB patients were registered in Tongzhou District of Beijing, among which 1344 cases were etiological negative, accounting for 42.9%. The incidence of etiological negative pulmonary TB showed a downward trend, decreasing from 21.6/100000 (309/1.428 million) in 2016 to 8.2/100000 (150/1.840 million) in 2020 ( {\chi }_{\mathrm{t}\mathrm{r}\mathrm{e}\mathrm{n}\mathrm{d}}^2=95.828,P=0.000).The male-female ratio of patients was 1.9∶1. The main age group was 15-44 years (67.4% (906/1344)). The main occupation were housekeepers/unemployed people (44.8% (602/1344)), staffs with fixed job (12.8% (172/1344)) and peasants (9.7% (131/1344)). The main source of patients was patients referred from general hospitals (71.3% (958/1344)). The non-local residents accounted for 61.6% (828/828), and most patients came from Hebei Province (25.7% (213/828)) and Heilongjiang Province (11.0% (91/1344)). All patients received full-course supervision and management. The overall treatment completion rate was 93.2% (1252/1344, over 90% for every year of the 5 years). Thirty-four cases (2.5%) defaulted,15 cases (1.1%) died, and 1 case (0.1%) developed multidrug-resistant TB. Conclusion: The epidemic of etiological negative pulmonary TB in Tongzhou District has declined from 2016 to 2020, people aged 15-44 years and peasants are high risk populations. It is of great importance to take comprehensive strategies for TB prevention and control.

Key words: Tuberculosis,pulmonary, Epidemiologic study characteristics as topic, Small-area analysis