Abstract:

Objective: To analyze the influencing factors of rifampicin resistance in pulmonary tuberculosis patients, and to provide scientific basis for effective control of drug-resistant tuberculosis in Kashgar. Methods: From January 1 to December 31, 2021, 144 rifampicin-resistant tuberculosis patients who were registered and received treatment in Kashgar Pulmonary Hospital and completed the survey were enrolled as the drug-resistant group based on the Tuberculosis Management Information System, a subsystem of the Chinese Disease Prevention and Control Information System. One hundred and forty-four bacteriology confirmed rifampicin-susceptible tuberculosis patients registered and treated in the same town during the same period were randomly selected as the non-drug-resistant group according to the principles of 1∶1 matching and age ±3 years. The laboratory test results, clinical diagnosis and treatment information were checked on-site, and an on-site questionnaire survey was carried out to collect the general demographic data of the patients, the status of receiving health education, and the patients’ tuberculosis treatment history and management. Univariate and multivariate logistic regression analysis was performed with rifampicin resistance as the dependent variable. Results: Multivariate analysis showed that the proportion of comorbidities, self-administration, non-metered medication, discontinuation of treatment, and unawareness of the transmission way of pulmonary tuberculosis among rifampicin-resistant patients (70.1% (101/144), 78.5% (113/144), 29.9% (43/144), 87.5% (126/144), 14.6% (21/144)) were significantly higher than those of non-rifampicin-resistant patients (26.4% (38/144), 16.0% (23/144), 15.3% (22/144), 6.9% (10/144), 2.8% (4/144)), which were independent risk factors for rifampicin resistance (OR (95%CI)=6.552 (3.987-10.768), 19.178 (11.109-33.103), 2.361 (1.335-4.174), 93.800 (48.909-179.894), 5.976 (2.228-16.026)). Conclusion: For pulmonary tuberculosis patients with comorbidities and low awareness of tuberculosis knowledge in Kashgar, interventions such as centralized medication management,and health education should be strengthened to improve patients’ treatment adherence and success rate, and to reduce the risk of acquired drug resistance.

Key words: Tuberculosis,pulmonary, Rifampicin, Drug resistance, Factor analysis, statistical, Kashgar