Abstract: Objective To evaluate the feasibility and safety of CT-guided percutaneous radiofrequency ablation (RFA) of pulmonary malignancies located in unusual regions.Methods Among 450 patients conducted CT-guided RFA in the Department of Thoracic Surgery in Xuanwu Hospital from July 2007 to December 2012, 100 cases with lung cancers located in unusual regions (mainly located within 1cm of diaphragmatic surface,hilum,side of superior vena cava,side of pulmonary trunk,side of aorta and side of heart) were enrolled in this study. All patients was performed CT-guided percutaneous RFA under local anesthesia.The time used for puncturing and putting the needles to the scheduled sites were recorded.The complications related the puncturing were observed.Results For all patients,the procedure of puncture and needle placement was completed in 5-10 minutes without any severe complications occurred. In patients with minor complications occurred, 9 (9.0%) had pneumothorax (among whom 2 (2.0%) cases needed closed drainage of pleural cavity), 3 cases (3.0%) had hemoptysis and 3 cases (3.0%) had pulmonary hemorrhage. 9 cases with pneumothorax recovered and left hospital, among whom 7 cases had been operated suction without closed drainage of pleural cavity. Three cases of hemoptysis recovered by hemostasis and radiofrequency ablation. Three cases with pulmonary hemorrhage improved 2 to 3 days after operation.Conclusion The result of this study indicates that CT-guided percutaneous RFA under local anesthesia is a feasible and a safe technique for the treatment of pulmonary malignancies located in unusual regions.