Research progress on Mycobacterium tuberculosis infection in family close contacts of pulmonary tuberculosis patients

doi:10.19983/j.issn.2096-8493.2024168

Abstract

Abstract:

Household close contacts (HCCs) of pulmonary tuberculosis (PTB) patients face a significantly elevated risk of Mycobacterium tuberculosis (MTB) infection compared to the general population, influenced by multifaceted determinants including sociodemographic characteristics, behavioral habits, health status, index case attributes, and household environmental factors, and also faced the diagnostic technology, screening guidelines and preventive treatment compliance to many challenges. In this paper, focusing on the epidemiological characteristics, diagnostic methods, influencing factors and preventive treatment of MTB infection in close family contacts were discussed by searching the relevant literatures published in PubMed, CNKI, Wanfang and other databases from 2015 to 2024.This study aims to provide a theoretical basis for subsequent relevant research while enhancing medical practitioners’ awareness of early screening and diagnosis for HCCs of PTB. The findings are expected to facilitate proactive acceptance of preventive treatment among this high-risk population, thereby fundamentally reducing TB incidence rates. Ultimately, this research contributes to achieving the global goal of End TB as a public health threat by 2035.

Key words: Tuberculosis, pulmonary, Family health, Contact tracing, Epidemiologic studies, Factor analysis, statistical, Protective agents

CLC Number:

R521

Cui Cancan, Li Mingwu. Research progress on Mycobacterium tuberculosis infection in family close contacts of pulmonary tuberculosis patients[J]. Journal of Tuberculosis and Lung Disease , 2025, 6(2): 234-240. doi: 10.19983/j.issn.2096-8493.2024168

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