Research progress on prognostic factors and integrated prevention and control strategies of tuberculosis and AIDS

doi:10.19983/j.issn.2096-8493.2024109

Abstract

Abstract:

Coinfection with tuberculosis and AIDS poses a significant public health challenge in China. The interplay between these two diseases complicates the identification of clinical characteristics, increases the complexity of treatment and management, accelerates disease progression, prolongs the anti-tuberculosis treatment course, and contributes to multiple complications, including opportunistic infections and drug resistance. The prognosis for patients with dual infection is generally poor. Enhancing the understanding of the unique challenges and dangers posed by Mycobacterium tuberculosis(MTB)/HIV coinfection, thoroughly investigating the various factors that influence patients’ quality of life and prognosis, and implementing precise, efficient, and comprehensive prevention and control measures at an early stage are crucial for improving disease outcomes and controlling these two major infectious diseases. The authors review the current status of tuberculosis complicated by AIDS, the unique challenges and risks associated with clinical coinfection, the factors influencing patient prognosis, and the comprehensive prevention and treatment strategies for comorbidity. The aim is to provide insights that may inform the optimization of management policies and the clinical prevention and treatment of patients with MTB/HIV coinfection.

Key words: Tuberculosis, Acquired immunodeficiency syndrome, Comorbidity, Review

CLC Number:

R52
R512.91

Yang Hongyu, Liu Qiaolin, Kang Xiong, Yang Xiaoli. Research progress on prognostic factors and integrated prevention and control strategies of tuberculosis and AIDS[J]. Journal of Tuberculosis and Lung Disease , 2024, 5(6): 590-596. doi: 10.19983/j.issn.2096-8493.2024109

References 57

[1]	Jesudason T. Global progress reported for AIDS. Lancet Infect Dis, 2023, 23(9):e342. doi:10.1016/S1473-3099(22)00684-3. pmid: 37633298
[2]	刘宇丹, 张彩云, 郭明媚, 等. 慢性病共病病人共享决策研究进展. 循证护理, 2024, 10(5): 831-836. doi:10.12102/j.issn.2095-8668.2024.05.012.
[3]	韩婷婷, 刘桂珍, 陈秋奇, 等. 世界卫生组织《应对结核病及其共病合作行动框架》解读. 中国防痨杂志, 2023, 45(1):25-30. doi:10.19982/j.issn.1000-6621.20220464.
[4]	舒薇, 刘宇红. 世界卫生组织《2023年全球结核病报告》解读. 结核与肺部疾病杂志, 2024, 5(1):15-19. doi:10.19983/j.issn.2096-8493.2024006.
[5]	卢春容, 谭卫国, 陆普选, 等. 2023年WHO全球结核病报告:全球与中国关键数据分析. 新发传染病电子杂志, 2023, 8(6): 73-78. doi:10.19871/j.cnki.xfcrbzz.2023.06.014.
[6]	World Health Organization. WHO consolidated guidelines on tuberculosis: tuberculosis preventive treatment: Module 1: prevention. Geneva: World Health Organization, 2020.
[7]	韩孟杰. 我国艾滋病流行形势分析和防治展望. 中国艾滋病性病, 2023, 29(3): 247-250. doi:10.13419/j.cnki.aids.2023.03.01.
[8]	何纳. 中国艾滋病流行病学研究新进展. 中华疾病控制杂志, 2021, 25(12): 1365-1368, 1480. doi:10.16462/j.cnki.zhjbkz.2021.12.001.
[9]	梁爽, 蒋轶文, 张岩, 等. 辽宁省2016—2021年结核杆菌和艾滋病病毒双重感染监测分析. 中国热带医学, 2024, 24(4): 422-425. doi:10.13604/j.cnki.46-1064/r.2024.04.11
[10]	袁晴, 范诗语, 马依迪丽·尼加提, 等. 喀什地区艾滋病与肺结核双重感染情况分析. 新疆医学, 2024, 54(2): 161-165.
[11]	张沛, 赵阿会, 高敏, 等. 2016—2021年河南省MTB/HIV双重感染流行特征分析. 中国防痨杂志, 2023, 45(4): 377-382. doi:10.19982/j.issn.1000-6621.20220366.
[12]	Cui Z, Huang F, Liang D, et al. Tuberculosis among Ambulatory People Living with HIV in Guangxi Province, China: A Longitudinal Study. Int J Environ Res Public Health, 2022, 19(19): 12280. doi:10.3390/ijerph191912280.
[13]	Qi TK, Chen J, Zhang RF, et al. A retrospective cohort study of early mortality among patients with HIV/TB co-infection in Shanghai municipality. HIV Med, 2020, 21(11):739-746. doi:10.1111/hiv.13025. pmid: 33369033
[14]	沈银忠. 《人类免疫缺陷病毒感染/艾滋病合并结核分枝杆菌感染诊治专家共识》解读. 诊断学理论与实践, 2022, 21(4):431-436. doi:10.16150/j.1671-2870.2022.04.003.
[15]	Bruchfeld J, Correia-Neves M, Källenius G. Tuberculosis and HIV Coinfection. Cold Spring Harb Perspect Med, 2015, 5(7):a017871. doi:10.1101/cshperspect.a017871.
[16]	郭静, 沈银忠. HIV感染/AIDS合并结核病的临床及免疫学特点研究进展. 诊断学理论与实践, 2021, 20(4): 401-406. doi:10.16150/j.1671-2870.2021.04.014.
[17]	吴雪韵, 沈银忠. 人类免疫缺陷病毒与结核分枝杆菌并发感染发病机制的研究进展. 内科理论与实践, 2019, 14(4): 253-258. doi:10.16138/j.1673-6087.a0983.
[18]	曹雪芳, 何勇鹏, 高磊. HIV/AIDS人群结核分枝杆菌感染现状及预防性治疗研究进展. 结核与肺部疾病杂志, 2022, 3(6): 511-516. doi:10.19983/j.issn.2096-8493.20220155.
[19]	Zenbaba D, Bonsa M, Sahiledengle B. Trends of unsuccessful treatment outcomes and associated factors among tuberculosis patients in public hospitals of Bale Zone, Southeast Ethiopia: A 5-year retrospective study. Heliyon, 2021, 7(9):e07982. doi:10.1016/j.heliyon.2021.e07982.
[20]	严菁敏, 陈莹, 于洁, 等. 基于LASSO-logistic回归的TB/HIV患者抗结核治疗结局影响因素研究. 现代预防医学, 2023, 50(22):4039-4045, 4051. doi:10.20043/j.cnki.MPM.202306338.
[21]	叶锦欣, 许琳, 陈金瓯, 等. 2011—2019年云南省结核病并发艾滋病患者抗结核治疗期间死亡影响因素分析. 中国防痨杂志, 2021, 43(2): 126-131. doi:10.3969/j.issn.1000-6621.2021.02005.
[22]	Qi CC, Xu LR, Zhao CJ, et al. Prevalence and risk factors of tuberculosis among people living with HIV/AIDS in China: a systematic review and meta-analysis. BMC Infect Dis, 2023, 23(1): 584. doi:10.1186/s12879-023-08575-4.
[23]	李颜玲, 任中业, 谢松松, 等. 肺结核患者不良治疗结局的相关危险因素分析. 中华传染病杂志, 2022, 40(10):620-624. doi:10.3760/cma.j.cn311365-20211208-00432.
[24]	杨妮, 苏茜, 肖月, 等. 2158例MTB/HIV双重感染患者治疗转归及影响因素分析. 中国防痨杂志, 2021, 43(3):274-279. doi:10.3969/j.issn.1000-6621.2021.03.014.
[25]	张哲, 汪宇, 张玲, 等. AIDS合并结核性脑膜炎患者的死亡风险因素分析. 传染病信息, 2019, 32(6):512-515. doi:10.3969/j.issn.1007-8134.2019.06.007.
[26]	田亚坤, 孙丽君, 姜太一, 等. 艾滋病合并结核分枝杆菌血症56例危险因素评估及特征分析. 标记免疫分析与临床, 2023, 30(4): 546-549. doi:10.11748/bjmy.issn.1006-1703.2023.04.002.
[27]	孙燕, 陈昭云, 杨萱, 等. 河南省487例艾滋病患者5种机会性感染临床特征及预后. 中国艾滋病性病, 2022, 28(12):1388-1391. doi:10.13419/j.cnki.aids.2022.12.10.
[28]	赵华, 张利, 李洪云, 等. 艾滋病患者合并机会性感染的临床特点及预后分析. 解放军医学院学报, 2021, 42(1):45-47, 52. doi:10.3969/j.issn.2095-5227.2021.01.010.
[29]	彭云, 邓勇, 辛力, 等. 艾滋病机会性感染种类及呼吸系统感染危险因素. 中华医院感染学杂志, 2023, 33(1):9-12. doi:10.11816/cn.ni.2023-213370.
[30]	Mohamud AK, Ahmed OA, Mohamud AA, et al. Magnitude of opportunistic infections and associated factors among adult people living with human immune deficient virus on art at selected public hospital, mogadishu somalia: cross-sectional study. Ann Med Surg (Lond), 2023, 85(7):3364-3371. doi:10.1097/MS9.0000000000000880. pmid: 37427157
[31]	Nabei JN, Bonful HA, Afari EA, et al. Predictors of quality of life of TB/HIV co-infected patients in the Northern region of Ghana. BMC Infect Dis, 2024, 24(1):396. doi:10.1186/s12879-024-09247-7. pmid: 38609839
[32]	Kanakaraj R, Umamaheswari R, Subramaniam S. Depression and its role in adherence to anti-retroviral treatment in people living with HIV and AIDS in Chennai. J Family Med Prim Care, 2024, 13(4):1507-1510. doi:10.4103/jfmpc.jfmpc_1533_23. pmid: 38827681
[33]	Tancredi MV, Sakabe S, Waldman EA. Mortality and survival of tuberculosis coinfected patients living with AIDS in São Paulo, Brazil: a 12-year cohort study. BMC Infect Dis, 2022, 22(1):223. doi:10.1186/s12879-022-07232-6. pmid: 35246066
[34]	Tesfayohannes S, Shine S, Mekuria A, et al. Mortality and Its Predictors among Adult Human Immune-Deficiency Virus-Infected Patients Attending Their Antiretroviral Treatment at Health Centers, Addis Ababa, Ethiopia: Multicenter Retrospective Cohort Study. AIDS Res Treat, 2022, 2022: 6128718. doi:10.1155/2022/6128718.
[35]	程耀, 陈洪德, 吴桂辉, 等. 成都市某医院结核重症监护室TB/HIV感染患者死亡相关因素分析. 临床肺科杂志, 2022, 27(11):1746-1750. doi:10.3969/j.issn.1009-6663.2022.11.023.
[36]	张驰, 刘林, 陈璎珞. 艾滋病患者营养筛查及其与合并症关系. 中国临床研究, 2020, 33(9):1232-1234. doi:10.13429/j.cnki.cjcr.2020.09.021.
[37]	孔含含, 刘燕群, 操静, 等. HIV/结核双重感染患者营养风险状况及影响因素分析. 护理学杂志, 2021, 36(18):39-41. doi:10.3870/j.issn.1001-4152.2021.18.039.
[38]	张金平, 刘菁. 肺结核患者HIV抗体筛查结果分析. 中国现代药物应用, 2023, 17(16):76-78. doi:10.14164/j.cnki.cn11-5581/r.2023.16.021.
[39]	罗丹, 陈松华, 张钰, 等. 2015—2021年浙江省MTB/HIV双重感染筛查现况及趋势分析. 结核与肺部疾病杂志, 2022, 3(6): 443-448. doi:10.19983/j.issn.2096-8493.20220132.
[40]	Uppal A, Rahman S, Campbell JR, et al. Economic and modeling evidence for tuberculosis preventive therapy among people living with HIV: A systematic review and meta-analysis. PLoS Med, 2021, 18(9):e1003712. doi:10.1371/journal.pmed.1003712.
[41]	Geremew D, Endalamaw A, Negash M, et al. The protective effect of isoniazid preventive therapy on tuberculosis incidence among HIV positive patients receiving ART in Ethiopian settings: a meta-analysis. BMC Infect Dis, 2019, 19(1):405. doi:10.1186/s12879-019-4031-2. pmid: 31077133
[42]	洪可, 张定宇, 阮连国. 武汉市HIV/AIDS患者潜伏性结核感染筛查及预防效果. 传染病信息, 2021, 34(5):422-425. doi:10.3969/j.issn.1007-8134.2021.05.008.
[43]	贾彦梅. 赋能教育在肺结核患者中的应用及对情绪障碍、心理韧性的影响. 中国健康心理学杂志, 2020, 28(1):41-46. doi:10.13342/j.cnki.cjhp.2020.01.011.
[44]	袁甜甜, 刘芳娥. 赋能教育在慢性病病人中的应用进展. 循证护理, 2019, 5(11):981-983. doi:10.12102/j.issn.2095-8668.2019.11.004.
[45]	石东辉. 社区护士对脑卒中偏瘫病人实施赋能教育的效果观察. 护理研究, 2019, 33(19): 3395-3398. doi:10.12102/j.issn.1009-6493.2019.19.021.
[46]	王秀芬, 罗蓝, 邓秋霞, 等. 赋能教育模式对艾滋病肺结核双重感染患者的影响. 齐鲁护理杂志, 2020, 26(21):76-78. doi:10.3969/j.issn.1006-7256.2020.21.025.
[47]	林冰. 协同护理对艾滋病肺结核双重感染患者自护能力、负性情绪及依从性的影响. 中国医药科学, 2019, 9(19):115-118. doi:10.3969/j.issn.2095-0616.2019.19.033.
[48]	叶蓓蕾. 舒适性干预对肺结核与艾滋病双重感染者治疗依从性的影响. 实用临床护理学电子杂志, 2020, 5(18):105,111.
[49]	袁欣, 徐园园, 朱正平, 等. 抗病毒治疗HIV/AIDS患者抑郁状况及其影响因素分析. 中山大学学报(医学科学版), 2024, 45(3): 438-445. doi:10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).20240425.001.
[50]	刘旭, 赵杨, 谭淑平, 等. 焦虑、抑郁情绪对艾滋病患者抗病毒治疗免疫学失败的影响及心理干预策略分析. 中国性科学, 2024, 33(3):135-140. doi:10.3969/j.issn.1672-1993.2024.03.032.
[51]	邓秋霞, 余骏雯, 叶丽丽, 等. HIV合并结核与单纯HIV感染患者焦虑抑郁症状网络特征的比较研究. 护士进修杂志, 2024, 39(6):561-570. doi:10.16821/j.cnki.hsjx.2024.06.001.
[52]	朱茜茜, 杨惠云. 聚焦解决模式在慢性病自我管理中的应用研究进展. 护理学杂志, 2024, 39(3): 126-128, 封3页. doi:10.3870/i.issn.1001-4152.2024.03.126.
[53]	张兵, 杨红丽, 栾玉泉, 等. 聚焦解决模式对HIV/AIDS患者焦虑抑郁和心理弹性的干预研究. 中国艾滋病性病, 2022, 28(9): 1050-1054. doi:10.13419/j.cnki.aids.2022.09.11.
[54]	黄巧荣, 杨连招, 陈玲, 等. 聚焦解决模式对HIV感染者/AIDS患者焦虑、抑郁影响的Meta分析. 中华护理杂志, 2023, 58(22):2792-2800. doi:10.3761/j.issn.0254-1769.2023.22.015.
[55]	刘云, 卢和丽, 邹卿, 等. 新发HIV/AIDS患者抑郁心理干预效果及其与CD4⁺T细胞计数的关系研究. 中国全科医学, 2024, 27(32): 4009-4014. doi:10.12114/j.issn.1007-9572.2023.0795.
[56]	侯思伟, 张斌, 张波, 等. 中医情志疗法对HIV/AIDS患者焦虑、抑郁及反刍思维的影响. 中医学报, 2023, 38(12):2684-2689. doi:10.16368/j.issn.1674-8999.2023.12.427.
[57]	潘程程, 张婷, 邓云, 等. 2015—2020年重庆市万州区结核菌/艾滋病病毒双重感染防治工作效果评价. 中国初级卫生保健, 2022, 36(5):55-57, 65. doi:10.3969/j.issn.1001-568X.2022.05.0015.