哮喘的气道重构机制研究进展

doi:10.19983/j.issn.2096-8493.20230036

摘要/Abstract

摘要：

哮喘是以慢性气道炎症性改变和可逆性气流受限为主要特征的全球性呼吸道疾病,典型临床症状为呼吸困难、咳嗽、胸闷和喘息等。哮喘患者的气道重构及持续性气流受限可发生在患病早期,并与哮喘患者的症状加重及用药息息相关。因此,早期识别干预可能成为哮喘患者治疗的重要方式。高分辨率计算机断层扫描作为一种非侵入性技术,越来越多地用于检查哮喘气道重构的不同方面。笔者针对高分辨率计算机断层扫描对哮喘患者的气道重构的诊断,以及近些年气道重构机制研究进展进行综述。

关键词: 气道阻塞, 哮喘, 体层摄影术, X线计算机

Abstract:

Asthma is a global respiratory disease characterized by chronic inflammation in the airway and reversible airway restriction. Typical clinical symptoms of asthma are dyspnea, cough, chest tightness, and wheezing, etc. The airway remodeling and persistent airflow restriction in asthmatic patients may occur in the early stage of the disease, and is closely related to exacerbation of symptoms and medication. Therefore, early identification intervention may become an important way to treat asthma patients. High-resolution computed tomography (HRCT), as a non-invasive technique, is increasingly used to examine different aspects of airway remodeling in asthma. In this paper, the diagnosis airway remodeling in asthmatics by HRCT and the mechanism of airway remodeling in recent years were reviewed.

Key words: Airway obstruction, Asthma, Tomography, X-ray computed

中图分类号:

R256.12
R81

王忠照, 唐昊. 哮喘的气道重构机制研究进展[J]. 结核与肺部疾病杂志, 2023, 4(2): 158-163. doi: 10.19983/j.issn.2096-8493.20230036

Wang Zhongzhao, Tang Hao. Research progress of airway remodeling mechanism in asthma[J]. Journal of Tuberculosis and Lung Disease, 2023, 4(2): 158-163. doi: 10.19983/j.issn.2096-8493.20230036

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